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Seronegative rheumatoid arthritis: Pathogenetic and therapeutic aspects

Lookup NU author(s): Dr Arthur Pratt, Professor John IsaacsORCiD


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Rheumatoid arthritis (RA) has long been recognised as a highly heterogeneous disease of immune dysregulation. Despite an ever-growing appreciation of the role of circulating autoantibodies in the development of 'seropositive' disease, the pathogenesis of seronegative RA remains poorly understood. Accumulating evidence suggests that RA 'serotypes', in fact, reflect distinct disease entities that, despite their clinical overlap, diverge in respect of genetic architecture, cellular pathology and even therapeutic responsiveness. Focussing on seronegative RA, this review considers these concepts and their implications for the management of patients with this challenging, though sometimes overlooked, condition. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Pratt AG, Isaacs JD

Publication type: Review

Publication status: Published

Journal: Best Practice & Research Clinical Rheumatology

Year: 2014

Volume: 28

Issue: 4

Pages: 651-659

Print publication date: 01/08/2014

Online publication date: 18/11/2014

ISSN (print): 1521-6942

ISSN (electronic): 1521-1770

Publisher: Elsevier


DOI: 10.1016/j.berh.2014.10.016