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The problems that exist when considering the anatomic variability between the channels that permit interventricular shunting

Lookup NU author(s): Professor Bob Anderson

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Abstract

Although steps are being taken to produce a universally acceptable coding system for categorisation of the congenitally malformed hearts, obstacles remain in the search for consensus. One of the groups of lesions continuing to produce the greatest problems is those that permit interventricular shunting. The difficulties relate partly to the words used to describe the group itself, as those using Germanic languages describe the holes as ventricular septal defects, whereas those using Romance languages consider them to represent interventricular communications. The two terms, however, are not necessarily synonymous. Further disagreements relate to whether the lesions placed within the group should be sub-categorised on the basis of their geographical location within the ventricular mass, as opposed to the anatomic nature of their borders. In reality, attention to both the features is necessary if we are to recognise the full extent of phenotypic variability. In this review, we first review the evolution and theories of analysis naming the channels that permit interventricular shunting. We then demonstrate that embryologic techniques provide evidence that the changing morphology of the developing murine heart parallels the anatomy of the different lesions encountered in the congenitally malformed human heart. We suggest that, with attention paid to the temporal development of the normal murine heart, combined with a strict definition of the plane of separation between the right and left ventricular cavities, it will be feasible to produce a categorisation that is acceptable to all.


Publication metadata

Author(s): Bailliard F, Spicer DE, Mohun TJ, Henry GW, Anderson RH

Publication type: Review

Publication status: Published

Journal: Cardiology in the Young

Year: 2015

Volume: 25

Issue: 1

Pages: 15-28

Print publication date: 01/01/2015

Online publication date: 27/05/2014

Acceptance date: 02/05/2014

ISSN (print): 1047-9511

ISSN (electronic): 1467-1107

Publisher: CAMBRIDGE UNIV PRESS

URL: http://dx.doi.org/10.1017/S1047951114000869

DOI: 10.1017/S1047951114000869


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