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Bioprocess intensification of antibiotic production by Streptomyces coelicolor A3(2) in micro-porous culture

Lookup NU author(s): Dr Teresa Ndlovu, Emeritus Professor Alan Ward, Professor Jarka Glassey, Professor Galip Akay


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A novel functionalized micro-porous matrix was developed with well-controlled physicochemical proprieties such as pore size and surface chemistry. The matrix was used as a solid support in the growth of "Streptomyces coelicolor" A3(2) to enhance the production of antibiotics. The results shown support a higher production of prodigiosin and actinorhodin with overall production increase of 2-5 and 6-17, respectively, compared to conventional submerged liquid culture, offering a potential improvement in volumetric productivity. Scanning Electron Microscopy was used to evaluate pore size as well as bacterial adhesion, penetration, proliferation and migration within the micro-porous matrix. (C) 2015 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Ndlovu TM, Ward AC, Glassey J, Eskildsen J, Akay G

Publication type: Article

Publication status: Published

Journal: Materials Science and Engineering C: Materials for Biological Applications

Year: 2015

Volume: 49

Pages: 799-806

Print publication date: 01/04/2015

Online publication date: 16/01/2015

Acceptance date: 14/01/2015

ISSN (print): 0928-4931

ISSN (electronic): 1873-0191

Publisher: Elsevier


DOI: 10.1016/j.msec.2015.01.052


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Funder referenceFunder name
Engineering and Physical Sciences Research Council (UK), Link
BH082471European Research Council
BH091866European Research Council
EP/E010725/1European Research Council
EP/F038453/1European Research Council