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Lookup NU author(s): Dr Gavin RichardsonORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Although it is accepted that the heart has a limited potential to regenerate cardiomyocytes following injury and that low levels of cardiomyocyte turnover occur during normal ageing, quantification of these events remains challenging. This is in part due to the rarity of the process, the contribution of multiple cellular sources to myocardial maintenance and the fact the DNA duplication within cardiomyocytes often leads to a polyploid cardiomyocyte, and only rarely leads to new cardiomyocytes by cellular division. We have therefore established a new nucleoside labelling protocol in order to trace the contribution of progenitor cells and cardiomyocyte division to the neo-cardiomyocyte population.
Author(s): Richardson GD
Publication type: Article
Publication status: Published
Journal: Journal of Visualized Experiments
Online publication date: 23/05/2016
Acceptance date: 04/08/2015
Date deposited: 04/08/2015
ISSN (electronic): 1940-087X
Publisher: Journal of Visualized Experiments
PubMed id: 27285379
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