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Lookup NU author(s): Dr Anne Oyewole,
Professor Mark Birch-MachinORCiD
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Redox homeostasis is maintained by the antioxidant defense system, which is responsible for eliminating a wide range of oxidants, including reactive oxygen species (ROS), lipid peroxides, and metals. Mitochondrial (mt)-localized antioxidants are widely studied because the mitochondria; the major producer of intracellular ROS, has been linked to the cause of aging and other chronic diseases. Mt-targeted antioxidants have shown great potential because they cross the mt phospholipid bilayer and eliminate ROS at the heart of the source. Growing evidence has identified mt-targeted antioxidants, such as MitoQ and tiron as potentially effective antioxidant therapies against the damage caused by enhanced ROS generation. This literature review summarizes the current knowledge on mt-targeted antioxidants and their contribution to the body's antioxidant defense system. In addition to addressing the concerns surrounding current antioxidant strategies, including difficulties in targeting antioxidant treatment to sites of pathologic oxidative damage, we discuss promising therapeutic agents and new strategic approaches.-Oyewole, A. O., Birch-Machin, M. A. Mitochondrial-targeted antioxidants.
Author(s): Oyewole A, Birch-Machin MA
Publication type: Review
Publication status: Published
Journal: FASEB Journal
Print publication date: 01/12/2015
Online publication date: 07/08/2015
Acceptance date: 03/08/2015
ISSN (print): 0892-6638
ISSN (electronic): 1530-6860
PubMed id: 26253366