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Lookup NU author(s): Dr Clare Guilding
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The suprachiasmatic nucleus of the hypothalamus (SCN) is the master circadian pacemaker or clock in the mammalian brain. Canonical theory holds that the output from this single, dominant clock is responsible for driving most daily rhythms in physiology and behaviour. However, important recent findings challenge this uniclock model and reveal clock-like activities in many neural and non-neural tissues. Thus, in addition to the SCN, a number of areas of the mammalian brain including the olfactory bulb, amygdala, lateral habenula and a variety of nuclei in the hypothalamus, express circadian rhythms in core clock gene expression, hormone output and electrical activity. This review examines the evidence for extra-SCN circadian oscillators in the mammalian brain and highlights some of the essential properties and key differences between brain oscillators. The demonstration of neural pacemakers outside the SCN has wide-ranging implications for models of the circadian system at a whole-organism level.
Author(s): Guilding C, Piggins HD
Publication type: Article
Publication status: Published
Journal: European Journal of Neuroscience
Print publication date: 01/06/2007
Online publication date: 06/06/2007
Acceptance date: 11/04/2007
Date deposited: 25/09/2015
ISSN (print): 0953-816X
ISSN (electronic): 1460-9568
Publisher: Wiley-Blackwell Publishing Ltd.
PubMed id: 17552989
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