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Lookup NU author(s): Professor Alison Yarnall, Dr Rachael LawsonORCiD, Dr Gordon Duncan, Dr Tien Kheng Khoo, Professor David BrooksORCiD, Professor John-Paul TaylorORCiD, Professor David BurnORCiD
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We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations
Author(s): Yarnall AJ, Lawson RA, Duncan GW, Breen DP, Khoo TK, Brooks D, Barker RA, Taylor JP, Burn DJ
Publication type: Article
Publication status: Published
Journal: Journal of Parkinson's Disease
Year: 2015
Volume: 5
Issue: 4
Pages: 743-743
Print publication date: 02/10/2015
Acceptance date: 01/01/1900
ISSN (print): 1877-7171
ISSN (electronic): 1877-718X
Publisher: IOS Press
URL: http://dx.doi.org/10.3233/JPD-150664
DOI: 10.3233/JPD-150664
PubMed id: 26444094
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