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Oxidative stress - a key emerging impact factor in health, ageing, lifestyle and aesthetics

Lookup NU author(s): Dr Amy Bowman, Professor Mark Birch-MachinORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Oxidative stress is the resultant damage that arises due to redox imbalances, more specifically an increase in destructive free radicals and reduction in protection from antioxidants and the antioxidant defence pathways. Oxidation of lipids by ROS can damage cellular structures and result in premature cell death. At low levels, ROS-induced oxidative stress can be prevented through the action of antioxidants, however, when ROS are present in excess, inflammation and cytotoxicity eventually results leading to cellular oxidative stress damage. Increasing evidence for the role of oxidative stress in various diseases including neurological, dermatological, and cardiovascular diseases is now emerging. Mitochondria are the principal source (90%) of ROS in the cell, with superoxide radicals being generated when molecular oxygen is combined with free electrons. Given the key role of mitochondria in the generation of cellular oxidative stress it is worth considering this organelle and the process in more detail and to provide methods of intervention

Publication metadata

Author(s): Kandola K, Bowman A, Birch-Machin MA

Publication type: Review

Publication status: Published

Journal: International Journal of Cosmetic Science

Year: 2015

Volume: 37

Issue: Supplement S2

Pages: 1-8

Print publication date: 01/12/2015

Online publication date: 17/11/2015

Acceptance date: 05/10/2013

ISSN (print): 0142-5463

ISSN (electronic): 1468-2494


DOI: 10.1111/ics.12287