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Cutaneous B-Lymphoblastic Lymphoma With IL3/IgH Translocation Presenting With Hypereosinophilia and Acute Endocarditis

Lookup NU author(s): Dr Simon BomkenORCiD, Dr Nicholas Bown, Dr Peter Carey, Dr Katrina Wood, Dr Kevin Windebank

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Abstract

Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia. Causation is unclear and likely to have multiple mechanisms. We report a six year old boy presenting with hypereosinophilia and associated Loeffler endocarditis. Three months following his initial hypereosinophilia he developed cutaneous B-lymphoblastic lymphoma. Re-analysis of apparently uninvolved bone marrow, taken at initial presentation, revealed a single, previously unidentified, t(5;14)(q31;q32) positive cell. Using fluorescent in situ hybridisation, we demonstrate IL3/IgH@ fusion in cutaneous lymphoma cells. Our case confirms the association of hypereosinophilia and B-lymphoblastic lymphoma and strengthens the association between IL3 hypersecretion and hypereosinophilia. Pediatr Blood Cancer 2015;62:1055-1057. (c) 2014 Wiley Periodicals, Inc.

Publication metadata

Author(s): Bomken S, Haigh S, Bown N, Carey P, Wood K, Windebank K

Publication type: Article

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2015

Volume: 62

Issue: 6

Pages: 1055-1057

Print publication date: 01/06/2015

Online publication date: 08/11/2014

Acceptance date: 23/09/2014

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.25318

DOI: 10.1002/pbc.25318

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