Publications by Dr Simon Bomken - ePrints

Browsing publications by Dr Simon Bomken.

Newcastle Authors	Title	Year
Dr Simon Bomken	ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies	2024
Dr Ricky Tirtakusuma Dr Paul Milne Dr Helen Blair Yuzhe Shi Dr Simon Bomken et al.	Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL	2024
Dr Simon Bomken Professor Matthew Collin	Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures	2024
Dr Simon Bomken	Effect of rituximab on immune status in children with mature B-cell non-Hodgkin lymphoma: a prespecified secondary analysis of the Inter-B-NHL Ritux 2010 trial	2023
Dr David Meikle Professor Fai Ng Dr Despina Televantou Dr Katrina Wood Dr Christopher Bacon et al.	Extranodal marginal zone lymphoma as the presenting feature of paediatric Sjögren syndrome	2023
Dr Christopher Bacon Dr Simon Bomken	How to recognize inborn errors of immunity in a child presenting with a malignancy: guidelines for the pediatric hemato-oncologist	2023
Dr Ugo Offor Dr Milos Ognjanovic Dr Gareth Parry Abbas Khushnood Professor Andrew Gennery et al.	Immunology of THymectomy And childhood CArdiac transplant (ITHACA): protocol for a UK-wide prospective observational cohort study to identify immunological risk factors of post-transplant lymphoproliferative disease (PTLD) in thymectomised children	2023
Dr Christopher Bacon Dr Simon Bomken	Improving outcomes of childhood and young adult non-Hodgkin lymphoma (NHL); twenty-five years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL)	2023
Dr Paul Milne Dr Simon Bomken Maymoon Madkhali Jamie Macdonald Dr Preeti Singh et al.	Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis	2023
Dr Simon Bomken Dr Amir Enshaei Dr Ed Schwalbe Dr Aneta Mikulasova Dr Masood Zaka et al.	Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement	2023
Dr Simon Bomken	The KMT2A recombinome of acute leukemias in 2023.	2023
Dr Simon Bomken Professor Andrew Gennery	Consensus Recommendations for the Clinical Management of Hematological Malignancies in Patients with DNA Double Stranded Break Disorders	2022
Dr Ugo Offor Professor Andrew Filby Dr Milos Ognjanovic Dr Gareth Parry Abbas Khushnood et al.	Defining the systemic immune landscape in children at an increased risk of posttransplant lymphoproliferative disease: The immunology of thymectomy and childhood cardiac transplant (ITHACA) study.	2022
Dr Ricky Tirtakusuma Dr Katarzyna Szoltysek Professor Vasily Grinev Dr Sirintra Nakjang Dr Daniel Williamson et al.	Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia	2022
Dr Alex Newman Dr Masood Zaka Dr Peixun Zhou Dr Alex Blain Dr Amy Erhorn et al.	Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma	2022
Dr Laura Jardine Dr Simone Webb Justin Engelbert Dr Owen Williams Professor Olaf Heidenreich et al.	Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia	2022
Dr Simon Bomken	Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis	2022
Dr Natalie Bell Dr Helen Blair Dr Simon Bomken	Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy	2021
Dr Simon Bomken	Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 pediatric patients	2021
Dr Simon Bomken	Second malignant neoplasms after treatment of non-Hodgkin’s lymphoma – A retrospective multinational study of 189 children and adolescents	2021
Dr Ugo Offor Dr Christopher Bacon Dr Jessica Roberts Jason Powell Dr Malcolm Brodlie et al.	Transplantation For Congenital Heart Disease Is Associated With An Increased Risk Of Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder In Children	2021
Dr Simon Bomken Professor Andrew Gennery	COVID-19 - Impact on childhood haematology patients	2020
Dr Ugo Offor Dr Sujith Samarasinghe Dr Kevin Windebank Professor Mary Slatter Professor Andrew Gennery et al.	HSCT provides effective treatment for lymphoproliferative disorders in children with primary immunodeficiency	2020
Professor Andrew Pearson Dr Simon Bomken	ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children	2019
Alex Newman Dr Masood Zaka Dr Peixun Zhou Dr Amy Erhorn Amy Barnard et al.	Biallelic Inactivation of TP53 is Associated with an Increased Risk of Relapse in Paediatric B-Cell Non-Hodgkin Lymphoma(B-NHL)	2019
Dr Simon Bomken	Identification of new Wilms tumour predisposition genes: an exome sequencing study	2019
Dr Simon Bomken	Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents	2019
Dr Peixun Zhou Dr Alex Blain Alex Newman Dr Masood Zaka Dr Ugo Offor et al.	Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif	2019
Dr Peixun Zhou Dr Amir Enshaei Alex Newman Dr Amy Erhorn Amy Barnard et al.	A genomic classification model enables risk stratification of paediatric endemic Burkitt lymphoma	2018
Dr Peixun Zhou Dr Amir Enshaei Alex Newman Dr Amy Erhorn Amy Barnard et al.	A Genomic Classification Model Enables Risk Stratification of Paediatric Endemic Burkitt Lymphona in Malawi	2018
Dr Ugo Offor Dr Christopher Bacon Professor Andrew Gennery Dr Simon Bomken	An increased risk of post-transplant lymphoproliferative disorder in children after cardiac transplantation for congenital heart disease	2018
Alex Newman Dr Masood Zaka Dr Peixun Zhou Dr Amy Erhorn Dr Rachel Crossland et al.	Biallelic inactivation of TP53 is associated with an increased risk of relapse in paediatric B-cell non-Hodgkin lymphoma (B-NHL)	2018
Dr Ugo Offor Dr Christopher Bacon Professor Andrew Gennery Dr Simon Bomken	Cardiac transplantation for congenital heart disease is associated with an increased risk of post-transplant lymphoproliferative disorder (PTLD) in children: a single centre experience	2018
Dr Simon Bomken	Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection	2018
Dr Simon Bomken Dr Christopher Bacon Professor Andrew Gennery	Current Understanding and Future Research Priorities in Malignancy Associated With Inborn Errors of Immunity and DNA Repair Disorders: The Perspective of an Interdisciplinary Working Group	2018
Alex Newman Dr Peixun Zhou Dr Masood Zaka Professor Christine Harrison FRCPath FMedSci Dr Simon Bomken et al.	Genomic landscape of adult and paediatric B-cell Non-Hodgkin lymphoma	2018
Dr Masood Zaka Dr Rachel Crossland Amy Barnard Sara Wilkinson Dr Simon Bomken et al.	Integrated analysis of the genomic and microRNA landscapes identifies dysregulated pathways associated with relapsed paediatric B-cell Non-Hodgkin lymphoma	2018
Dr Peixun Zhou Alex Newman Filbert Adlar Casey Broadbent Dr Alison Blain et al.	Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma	2018
Dr Lynsey McKenzie Hasan Issa Sandeep Potluri Dr Helen Blair Asmida Isa et al.	The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation	2018
Dr Alex Elder Dr Simon Bomken Dr Ian Wilson Dr Helen Blair Dr Simon Cockell et al.	Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia	2017
Dr Paul Milne Dr Venetia Bigley Dr Christopher Bacon Dr Naomi McGovern Dr Simon Bomken et al.	Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults	2017
Dr Richard Noble Dr Natalie Bell Dr Helen Blair Huw Thomas Nicole Phillips et al.	Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma	2017
Dr Venetia Bigley Dr Simon Bomken Professor Matthew Collin	National Web-Based Meetings Help to Identify Histiocytosis Patients with Refractory Disease or Sequelae who Need Individualised or Novel Treatment Strategies	2016
Dr Simon Bomken	Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases	2016
Dr Simon Bomken	Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents	2016
Dr Alex Elder Dr Klaus Rehe Dr Simon Bomken Dr Paul Sinclair Katie Dormon et al.	The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.	2016
Dr Klaus Rehe Dr Simon Bomken Dr Paul Sinclair Dr Lisa Russell Professor Olaf Heidenreich et al.	Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier	2015
Dr Simon Bomken Dr Nicholas Bown Dr Peter Carey Dr Katrina Wood Dr Kevin Windebank et al.	Cutaneous B-Lymphoblastic Lymphoma With IL3/IgH Translocation Presenting With Hypereosinophilia and Acute Endocarditis	2015
Dr Alex Elder Dr Helen Blair Katie Dormon Dr Simon Bomken Dr Simon Cockell et al.	High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity	2015
Dr Natalie Bell Dr Helen Blair Lisa Price Dr Katrina Wood Professor Hermann Josef Vormoor et al.	Patient-derived xenograft and in vivo bioluminescent modelling of B-cell NHL	2015
Dr Simon Bomken Professor Roderick Skinner	Second Malignant Neoplasms Following Haematopoietic Stem Cell Transplantation in Childhood	2015
Dr Frida Ponthan Dr Simon Bomken Dr Deepali Pal Dr Alex Elder Hesta McNeill et al.	A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL	2014
Dr Natalie Bell Dr Helen Blair Professor Hermann Josef Vormoor Dr Christopher Bacon Dr Vikki Rand et al.	Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing	2014
Dr Alex Elder Dr Simon Bomken Dr Helen Blair Professor Hermann Josef Vormoor Professor Olaf Heidenreich et al.	Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia	2014
Dr Simon Bomken Dr Helen Blair Professor Hermann Josef Vormoor Professor Olaf Heidenreich	Preclinical modelling of childhood acute lymphoblastic leukaemia	2014
Dr Klaus Rehe Kerrie Wilson Dr Simon Bomken Dr Daniel Williamson Professor Julie Irving et al.	Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations	2013
Dr Simon Bomken Dr Lars Buechler Dr Klaus Rehe Dr Frida Ponthan Dr Alex Elder et al.	Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression	2013
Dr Sarah Fordham Dr Victoria Forster Professor Graham Jackson Dr Simon Bomken Professor James Allan et al.	A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia	2012
Dr Lindsay Nicholson Elizabeth Matheson Lynne Minto Marian Case Maryna Sanichar et al.	Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia	2012
Dr Simon Bomken Dr Kevin Windebank Professor Roderick Skinner	Salvage of multiply relapsed Burkitt's non-Hodgkin lymphoma by matched-unrelated donor haematopoietic stem cell transplantation	2012
Dr Klaus Rehe Kerrie Wilson Dr Simon Bomken Professor Olaf Heidenreich Professor Hermann Josef Vormoor et al.	In acute lymphoblastic leukaemia stemness is frequent and ubiquitous	2011
Dr Simon Bomken Dr Lars Buechler Dr Klaus Rehe Dr Frida Ponthan Dr Helen Blair et al.	Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance	2011
Dr Simon Bomken Dr Barry Davies Mike Cole Dr Katrina Wood Maritsa McDermott et al.	Percentage tumor necrosis following chemotherapy in neuroblastoma correlates with MYCN status but not survival	2011
Dr Nicola Sunter Professor Graham Jackson Dr Simon Bomken Professor James Allan	A Functional Polymorphism In the CD95 Cell Death Receptor Associated with Prognosis In Acute Promyelocytic Leukemia	2010
Professor Graham Jackson Dr Simon Bomken Professor James Allan	A Functional Polymorphism In the CD95 Cell Death Receptor Associated with Prognosis In Acute Promyelocytic Leukemia	2010
Patricia Garrido Castro Dr Simon Bomken Elda Latif Michael Batey Hesta McNeill et al.	ANGIOPOIETIN1 a Novel Factor Implicated In MLL Rearranged Acute Lymphoblastic Leukemia and Regulated In a Fusion Gene Dependent Manner	2010
Patricia Garrido Castro Dr Simon Bomken Professor Hermann Josef Vormoor Professor Olaf Heidenreich	ANGIOPOIETIN-1 expression is modulated by leukaemic fusion genes	2010
Dr Klaus Rehe Kerrie Wilson Dr Simon Bomken Hesta McNeill Professor Julie Irving et al.	In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous	2010
Dr Klaus Rehe Kerrie Wilson Dr Simon Bomken Hesta McNeill Professor Julie Irving et al.	In Acute Lymphoblastic Leukaemia, Sternness Is Frequent and Ubiquitous	2010
Dr Klaus Rehe Kerrie Wilson Dr Simon Bomken Hesta McNeill Professor Julie Irving et al.	In acute lymphoblastic leukemia, stemness is frequent and ubiquitous	2010
Dr Simon Bomken Dr Svetlana Mysina Professor Olaf Heidenreich Professor Hermann Josef Vormoor	The Germline Stem Cell Self-Renewal Gene PIWIL2 is Expressed in Both Malignant and Non-Malignant Lymphoid Cells	2010
Dr Simon Bomken Professor Hermann Josef Vormoor Professor Olaf Heidenreich	The Prosurvival Cytokine Angiopoietin-1 is Overexpressed in T(4;11)-Positive ALL and Regulated in a MLL/AF4 Dependent Manner	2010
Dr Simon Bomken Dr Karel Fiser Professor Olaf Heidenreich Professor Hermann Josef Vormoor	Understanding the cancer stem cell	2010
Dr Simon Bomken Professor Hermann Josef Vormoor	Childhood leukaemia	2009
Dr Simon Bomken Kerrie Wilson Professor Julie Irving Professor Hermann Josef Vormoor	In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties	2008
Kerrie Wilson Dr Klaus Rehe Dr Simon Bomken Marian Case Professor Julie Irving et al.	In Childhood ALL, Both Blasts with a CD20(-/Low) and a CD20(High) Immunophenotype, Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y-/- Mice	2008
Dr Simon Bomken Dr Barry Davies Dr Katrina Wood Professor Deborah Tweddle	Tumour necrosis following chemotherapy in neuroblastoma correlates with MYC-N status but not survival	2007
Dr Simon Bomken Dr Katrina Wood Dr Michael Reid Professor Deborah Tweddle	Limitations in the ability of NB84 to detect metastatic neuroblastoma cells in bone marrow	2006