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Browsing publications by Dr Simon Bomken.

Newcastle AuthorsTitleYearFull text
Dr Simon Bomken
Professor Andrew Gennery
Consensus Recommendations for the Clinical Management of Hematological Malignancies in Patients with DNA Double Stranded Break Disorders2022
Dr Simon Bomken
Dr Amir Enshaei
Dr Ed Schwalbe
Dr Aneta Mikulasova
Dr Masood Zaka
et al.
Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement2022
Dr Laura Jardine
Dr Simone Webb
Justin Engelbert
Dr Owen Williams
Professor Olaf Heidenreich
et al.
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia2022
Dr Alex Newman
Dr Masood Zaka
Dr Peixun Zhou
Alex Blain
Dr Amy Erhorn
et al.
Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma2021
Dr Natalie Bell
Dr Helen Blair
Dr Simon Bomken
Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy2021
Dr Simon Bomken
Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 pediatric patients2021
Dr Simon Bomken
Second malignant neoplasms after treatment of non-Hodgkin’s lymphoma – A retrospective multinational study of 189 children and adolescents2021
Dr Simon Bomken
Professor Andrew Gennery
COVID-19 - Impact on childhood haematology patients2020
Dr Ugo Offor
Dr Sujith Samarasinghe
Dr Kevin Windebank
Dr Mary Slatter
Professor Andrew Gennery
et al.
HSCT provides effective treatment for lymphoproliferative disorders in children with primary immunodeficiency2020
Dr Ugo Offor
Dr Christopher Bacon
Dr Jessica Roberts
Jason Powell
Dr Malcolm Brodlie
et al.
Transplantation For Congenital Heart Disease Is Associated With An Increased Risk Of Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder In Children2020
Professor Andrew Pearson
Dr Simon Bomken
ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children2019
Alex Newman
Dr Masood Zaka
Dr Peixun Zhou
Dr Amy Erhorn
Amy Barnard
et al.
Biallelic Inactivation of TP53 is Associated with an Increased Risk of Relapse in Paediatric B-Cell Non-Hodgkin Lymphoma(B-NHL)2019
Dr Simon Bomken
Identification of new Wilms tumour predisposition genes: an exome sequencing study2019
Dr Simon Bomken
Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents2019
Dr Peixun Zhou
Alex Blain
Alex Newman
Dr Masood Zaka
Dr Ugo Offor
et al.
Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif2019
Dr Peixun Zhou
Dr Amir Enshaei
Alex Newman
Dr Amy Erhorn
Amy Barnard
et al.
A genomic classification model enables risk stratification of paediatric endemic Burkitt lymphoma2018
Dr Peixun Zhou
Dr Amir Enshaei
Alex Newman
Dr Amy Erhorn
Amy Barnard
et al.
A Genomic Classification Model Enables Risk Stratification of Paediatric Endemic Burkitt Lymphona in Malawi2018
Dr Ugo Offor
Dr Christopher Bacon
Professor Andrew Gennery
Dr Simon Bomken
An increased risk of post-transplant lymphoproliferative disorder in children after cardiac transplantation for congenital heart disease2018
Alex Newman
Dr Masood Zaka
Dr Peixun Zhou
Dr Amy Erhorn
Dr Rachel Crossland
et al.
Biallelic inactivation of TP53 is associated with an increased risk of relapse in paediatric B-cell non-Hodgkin lymphoma (B-NHL)2018
Dr Ugo Offor
Dr Christopher Bacon
Professor Andrew Gennery
Dr Simon Bomken
Cardiac transplantation for congenital heart disease is associated with an increased risk of post-transplant lymphoproliferative disorder (PTLD) in children: a single centre experience2018
Dr Simon Bomken
Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection2018
Dr Simon Bomken
Dr Christopher Bacon
Professor Andrew Gennery
Current Understanding and Future Research Priorities in Malignancy Associated With Inborn Errors of Immunity and DNA Repair Disorders: The Perspective of an Interdisciplinary Working Group2018
Alex Newman
Dr Peixun Zhou
Dr Masood Zaka
Professor Christine Harrison FRCPath FMedSci
Dr Simon Bomken
et al.
Genomic landscape of adult and paediatric B-cell Non-Hodgkin lymphoma2018
Dr Masood Zaka
Dr Rachel Crossland
Amy Barnard
Sara Wilkinson
Dr Simon Bomken
et al.
Integrated analysis of the genomic and microRNA landscapes identifies dysregulated pathways associated with relapsed paediatric B-cell Non-Hodgkin lymphoma2018
Dr Peixun Zhou
Alex Newman
Filbert Adlar
Casey Broadbent
Dr Alison Blain
et al.
Investigation of FOXO1 mutations in paediatric endemic and sporadic Burkitt lymphoma2018
Dr Lynsey McKenzie
Hasan Issa
Sandeep Potluri
Dr Helen Blair
Asmida Isa
et al.
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation2018
Dr Alex Elder
Dr Simon Bomken
Dr Ian Wilson
Dr Helen Blair
Dr Simon Cockell
et al.
Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia2017
Dr Paul Milne
Dr Venetia Bigley
Dr Christopher Bacon
Dr Naomi McGovern
Dr Simon Bomken
et al.
Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults2017
Dr Richard Noble
Dr Natalie Bell
Dr Helen Blair
Huw Thomas
Nicole Phillips
et al.
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma2017
Dr Venetia Bigley
Dr Simon Bomken
Professor Matthew Collin
National Web-Based Meetings Help to Identify Histiocytosis Patients with Refractory Disease or Sequelae who Need Individualised or Novel Treatment Strategies2016
Dr Simon Bomken
Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases2016
Dr Simon Bomken
Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents2016
Dr Alex Elder
Dr Klaus Rehe
Dr Simon Bomken
Dr Paul Sinclair
Katie Dormon
et al.
The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.2016
Dr Klaus Rehe
Dr Simon Bomken
Dr Paul Sinclair
Dr Lisa Russell
Professor Olaf Heidenreich
et al.
Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier2015
Dr Simon Bomken
Dr Nicholas Bown
Dr Peter Carey
Dr Katrina Wood
Dr Kevin Windebank
et al.
Cutaneous B-Lymphoblastic Lymphoma With IL3/IgH Translocation Presenting With Hypereosinophilia and Acute Endocarditis2015
Dr Alex Elder
Dr Helen Blair
Katie Dormon
Dr Simon Bomken
Dr Simon Cockell
et al.
High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity2015
Dr Natalie Bell
Dr Helen Blair
Lisa Price
Dr Katrina Wood
Professor Hermann Josef Vormoor
et al.
Patient-derived xenograft and in vivo bioluminescent modelling of B-cell NHL2015
Dr Simon Bomken
Professor Roderick Skinner
Second Malignant Neoplasms Following Haematopoietic Stem Cell Transplantation in Childhood2015
Dr Frida Ponthan
Dr Simon Bomken
Dr Deepali Pal
Dr Alex Elder
Hesta McNeill
et al.
A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL2014
Dr Natalie Bell
Dr Helen Blair
Professor Hermann Josef Vormoor
Dr Christopher Bacon
Dr Vikki Rand
et al.
Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing2014
Dr Alex Elder
Dr Simon Bomken
Dr Helen Blair
Professor Hermann Josef Vormoor
Professor Olaf Heidenreich
et al.
Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia2014
Dr Simon Bomken
Dr Helen Blair
Professor Hermann Josef Vormoor
Professor Olaf Heidenreich
Preclinical modelling of childhood acute lymphoblastic leukaemia2014
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Dr Daniel Williamson
Professor Julie Irving
et al.
Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations2013
Dr Simon Bomken
Dr Lars Buechler
Dr Klaus Rehe
Dr Frida Ponthan
Dr Alex Elder
et al.
Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression2013
Dr Sarah Fordham
Dr Victoria Forster
Professor Graham Jackson
Dr Simon Bomken
Professor James Allan
et al.
A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia2012
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Marian Case
Maryna Sanichar
et al.
Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia2012
Dr Simon Bomken
Dr Kevin Windebank
Professor Roderick Skinner
Salvage of multiply relapsed Burkitt's non-Hodgkin lymphoma by matched-unrelated donor haematopoietic stem cell transplantation2012
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Professor Olaf Heidenreich
Professor Hermann Josef Vormoor
et al.
In acute lymphoblastic leukaemia stemness is frequent and ubiquitous2011
Dr Simon Bomken
Dr Lars Buechler
Dr Klaus Rehe
Dr Frida Ponthan
Dr Helen Blair
et al.
Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance2011
Dr Simon Bomken
Dr Barry Davies
Mike Cole
Dr Katrina Wood
Maritsa McDermott
et al.
Percentage tumor necrosis following chemotherapy in neuroblastoma correlates with MYCN status but not survival2011
Dr Nicola Sunter
Professor Graham Jackson
Dr Simon Bomken
Professor James Allan
A Functional Polymorphism In the CD95 Cell Death Receptor Associated with Prognosis In Acute Promyelocytic Leukemia2010
Professor Graham Jackson
Dr Simon Bomken
Professor James Allan
A Functional Polymorphism In the CD95 Cell Death Receptor Associated with Prognosis In Acute Promyelocytic Leukemia2010
Patricia Garrido Castro
Dr Simon Bomken
Elda Latif
Michael Batey
Hesta McNeill
et al.
ANGIOPOIETIN1 a Novel Factor Implicated In MLL Rearranged Acute Lymphoblastic Leukemia and Regulated In a Fusion Gene Dependent Manner2010
Patricia Garrido Castro
Dr Simon Bomken
Professor Hermann Josef Vormoor
Professor Olaf Heidenreich
ANGIOPOIETIN-1 expression is modulated by leukaemic fusion genes2010
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Hesta McNeill
Professor Julie Irving
et al.
In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous2010
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Hesta McNeill
Professor Julie Irving
et al.
In Acute Lymphoblastic Leukaemia, Sternness Is Frequent and Ubiquitous2010
Dr Klaus Rehe
Kerrie Wilson
Dr Simon Bomken
Hesta McNeill
Professor Julie Irving
et al.
In acute lymphoblastic leukemia, stemness is frequent and ubiquitous2010
Dr Simon Bomken
Dr Svetlana Mysina
Professor Olaf Heidenreich
Professor Hermann Josef Vormoor
The Germline Stem Cell Self-Renewal Gene PIWIL2 is Expressed in Both Malignant and Non-Malignant Lymphoid Cells2010
Dr Simon Bomken
Professor Hermann Josef Vormoor
Professor Olaf Heidenreich
The Prosurvival Cytokine Angiopoietin-1 is Overexpressed in T(4;11)-Positive ALL and Regulated in a MLL/AF4 Dependent Manner2010
Dr Simon Bomken
Dr Karel Fiser
Professor Olaf Heidenreich
Professor Hermann Josef Vormoor
Understanding the cancer stem cell2010
Dr Simon Bomken
Professor Hermann Josef Vormoor
Childhood leukaemia2009
Dr Simon Bomken
Kerrie Wilson
Professor Julie Irving
Professor Hermann Josef Vormoor
In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties2008
Kerrie Wilson
Dr Klaus Rehe
Dr Simon Bomken
Marian Case
Professor Julie Irving
et al.
In Childhood ALL, Both Blasts with a CD20(-/Low) and a CD20(High) Immunophenotype, Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y-/- Mice2008
Dr Simon Bomken
Dr Barry Davies
Dr Katrina Wood
Professor Deborah Tweddle
Tumour necrosis following chemotherapy in neuroblastoma correlates with MYC-N status but not survival2007
Dr Simon Bomken
Dr Katrina Wood
Dr Michael Reid
Professor Deborah Tweddle
Limitations in the ability of NB84 to detect metastatic neuroblastoma cells in bone marrow2006