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Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder

Lookup NU author(s): Emeritus Professor Jan Scott


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ObjectiveIt is suggested that age at onset (AAO) of bipolar I disorder (BP-I) is decreasing. We tested for a birth-cohort effect on AAO using admixture analysis.MethodA clinical sample of 3896 BP-I cases was analysed using two approaches: (i) in a subsample with untruncated AAOxbirth year distribution (n=1865), we compared the best-fitting model for the observed AAO in patients born 1960 and >1960, (ii) to control for potential confounders, two separate subsamples born 1960 and >1960 were matched for age at interview (n=250), and a further admixture analysis was undertaken.ResultsThe two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP-I cases born >1960.ConclusionThe decrease in AAO of BP-I in recent birth-cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania.

Publication metadata

Author(s): Golmard JL, Scott J, Etain B, Preisig M, Aubry JM, Henry C, Jamain S, Azorin JM, Leboyer M, Bellivier F

Publication type: Article

Publication status: Published

Journal: Acta Psychiatrica Scandinavica

Year: 2016

Volume: 133

Issue: 3

Pages: 205-213

Print publication date: 01/03/2016

Online publication date: 07/08/2015

Acceptance date: 10/07/2015

ISSN (print): 0001-690X

ISSN (electronic): 1600-0447

Publisher: Wiley-Blackwell


DOI: 10.1111/acps.12478


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Funder referenceFunder name
Institut National de la Sante et de la Recherche Medicale (INSERM)
Fondation FondaMental
32-049746.96Swiss National Science Foundation
32-40677.94Swiss National Science Foundation
AOM98152Ministere de la Recherche (PHRC)
CRC 94232Assistance Publique-Hopitaux de Paris