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Lookup NU author(s): Dr Mauro Santibanez Koref,
Professor Christine Harrison FRCPath FMedSci
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We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.
Author(s): Menasce LP, Orphanos V, Santibanez-Koref MF, Boyle JM, Harrison CJ
Publication type: Article
Publication status: Published
Journal: Genes, Chromosomes Cancer
ISSN (print): 1045-2257
ISSN (electronic): 1098-2264
Publisher: John Wiley & Sons, Inc.
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