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Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia

Lookup NU author(s): Dr Mauro Santibanez Koref, Professor Christine Harrison FRCPath FMedSci

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Abstract

We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.

Publication metadata

Author(s): Menasce LP, Orphanos V, Santibanez-Koref MF, Boyle JM, Harrison CJ

Publication type: Article

Publication status: Published

Journal: Genes, Chromosomes Cancer

Year: 1994

Volume: 10

Issue: 1

Pages: 26-29

ISSN (print): 1045-2257

ISSN (electronic): 1098-2264

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/gcc.2870100105

DOI: 10.1002/gcc.2870100105

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