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Imposed rate and extent of weight loss, in obese men and adaptive changes in resting and total energy expenditure

Lookup NU author(s): Dr Mario Siervo, Dr Jose Lara-Gallegos, Eileen Gibney


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Objectives. Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different changes in total and resting EE and if (2) they influenced the level of adaptive thermogenesis, defined as the decline in total or resting EE not accounted by changes in body composition.Methods. Three groups of six, obese men participated in a total fast for 6 days to achieve a 5% WL and a very low calorie (VLCD, 2.5 MJ/day) for 3 weeks or a low calorie (LCD, 5.2 MJ/clay) diet for 6 weeks to achieve a 10% WL. A four-component model was used to measure body composition. Indirect calorimetry was used to measure resting EE. Total EE was measured by doubly labelled water (VLCD, LCD) and 24-hour whole-body calorimetry (fasting).Results. VLCD and LCD showed a similar degree of metabolic adaptation for total EE (VLCD = -6.2%; LCD = -6.8%). Metabolic adaptation for resting EE was greater in the LCD (-0.4 MJ/day, -5.3%) compared to the VLCD (-0.1 MJ/day, -1.4%) group. Resting EE did not decrease after short-term fasting and no evidence of adaptive thermogenesis (+0.4 MJ/day) was found after 5% WL. The rate of WL was inversely associated with changes in resting EE (n = 30, r = 0.-42, p = 0.01).Conclusions. The rate of WL did not appear to influence the decline in total EE in obese men after 10% WL. Approximately 6% of this decline in total EE was explained by mechanisms of adaptive thermogenesis. (C) 2015 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Siervo M, Faber P, Lara J, Gibney ER, Milne E, Ritz P, Lobley GE, Elia M, Stubbs RJ, Johnstone AM

Publication type: Article

Publication status: Published

Journal: Metabolism

Year: 2015

Volume: 64

Issue: 8

Pages: 896-904

Print publication date: 01/08/2015

Online publication date: 08/04/2015

Acceptance date: 17/03/2015

ISSN (print): 0026-0495

ISSN (electronic): 1532-8600

Publisher: W.B. Saunders Co.


DOI: 10.1016/j.metabol.2015.03.011


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