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The structural basis for C-banding

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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The same C-banded human polymorphic chromosomes were observed in the light microscope (LM) and then in the scanning electron microscope (SEM) to investigate the structural changes produced by the C-banding technique. C-banded regions, which stained positively in LM, were highly condensed with tightly packed chromatin fibres, resembling non-banded chromosomes. In striking contrast, adjacent non-C-banded regions were represented by loosely arranged fibres, resembling G-banded chromosomes. The significance of these observations in relation to current theories on the effects of C-banding on chromosome structure is discussed.

Publication metadata

Author(s): Jack EM, Harrison CJ, Allen TD, Harris R

Publication type: Article

Publication status: Published

Journal: Chromosoma

Year: 1985

Volume: 91

Issue: 5

Pages: 363-368

Print publication date: 01/04/1985

ISSN (print): 0009-5915

ISSN (electronic): 1432-0886

Publisher: Springer


DOI: 10.1007/BF00291009

Notes: Journal Article Research Support, Non-U.S. Gov't Germany, west


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