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Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci
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The same C-banded human polymorphic chromosomes were observed in the light microscope (LM) and then in the scanning electron microscope (SEM) to investigate the structural changes produced by the C-banding technique. C-banded regions, which stained positively in LM, were highly condensed with tightly packed chromatin fibres, resembling non-banded chromosomes. In striking contrast, adjacent non-C-banded regions were represented by loosely arranged fibres, resembling G-banded chromosomes. The significance of these observations in relation to current theories on the effects of C-banding on chromosome structure is discussed.
Author(s): Jack EM, Harrison CJ, Allen TD, Harris R
Publication type: Article
Publication status: Published
Journal: Chromosoma
Year: 1985
Volume: 91
Issue: 5
Pages: 363-368
Print publication date: 01/04/1985
ISSN (print): 0009-5915
ISSN (electronic): 1432-0886
Publisher: Springer
URL: http://dx.doi.org/10.1007/BF00291009
DOI: 10.1007/BF00291009
Notes: Journal Article Research Support, Non-U.S. Gov't Germany, west
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