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Lookup NU author(s): Dr Patrick Yu Wai Man
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As a group, inherited optic neuropathies represent an important cause of severe irreversible visual loss among children and young adults. Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA) are the two most common forms encountered in clinical practice and several shared disease pathways have emerged that contribute to retinal ganglion cell loss, and eventually visual failure. In this review, the author critically appraises the evidence base for the various therapeutic strategies that have been put forward to treat these two mitochondrially determined optic neuropathies, including future developments. Innovative in vitro fertilization techniques to prevent female carriers of childbearing age from transmitting pathogenic mitochondrial DNA mutations to their biological children will also be discussed.
Author(s): Yu-Wai-Man P
Publication type: Article
Publication status: Published
Journal: Seminars in Neurology
Print publication date: 01/10/2015
Acceptance date: 01/01/1900
ISSN (print): 0271-8235
ISSN (electronic): 1098-9021
Publisher: Thieme Medical Publishers, Inc.
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