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Emerging and Disease-Specific Mechanisms of Hepatic Stellate Cell Activation

Lookup NU author(s): Professor Derek Mann


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The last decade has seen a rapid expansion in our understanding of the mechanisms leading to hepatic stellate cell activation. The classic activation pathway of initiation, perpetuation and regression remains as a useful model; however, the emergence of several new pathways and mediators has revealed a deeper complexity than previously appreciated. Although core fibrogenic pathways exist across organs and disease types, there is accumulating evidence for disease-and context-specific mechanisms that may modulate or drive hepatic fibrogenesis. Hence, a "one size fits all" approach to antifibrotic therapy may not be appropriate for all disease settings. The authors present a focused and concise update of the most recent advances in our understanding of hepatic stellate cell activation pathways, while highlighting several challenges that may be constraining progress. This summary provides a foundation to further expand our knowledge of this unique cell type and its contributions to human liver disease.

Publication metadata

Author(s): Wallace MC, Friedman SL, Mann DA

Publication type: Review

Publication status: Published

Journal: Seminars in Liver Disease

Year: 2015

Volume: 35

Issue: 2

Pages: 107-118

Print publication date: 01/05/2015

Acceptance date: 01/01/1900

ISSN (print): 0272-8087

ISSN (electronic): 1098-8971



DOI: 10.1055/s-0035-1550060