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Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci
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Human chromosome polymorphisms were investigated by scanning electron microscopy (SEM). Centromeric heterochromatin was of a constricted morphology. The extent of the C banded region was demarcated by a prominent circumferential groove in G banded chromosomes. Circumferential grooves were observed within the heterochromatin of chromosome 9, and the number of grooves present reflected the size of the region. Three dimensional viewing of satellites and short arms of acrocentric chromosomes, from different angles in the SEM, provided the opportunity for accurate assessment of the size of satellites to be made. Also, small morphological variations were defined in the SEM when definition was uncertain in the light microscope (LM).
Author(s): Harrison CJ, Jack EM, Allen TD, Harris R
Publication type: Article
Publication status: Published
Journal: Journal of Medical Genetics
Print publication date: 01/02/1985
ISSN (print): 0022-2593
ISSN (electronic): 1468-6244
Publisher: BMJ Group
Notes: Journal Article
Research Support, Non-U.S. Gov't
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