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Arrhythmias in Adult Congenital Patients With Bodily Isomerism

Lookup NU author(s): Professor Bob Anderson


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There are an increasing number of adults with congenital heart disease, some of whom have bodily isomerism. Bodily isomerism or heterotaxy is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of arrhythmias in adults with bodily isomerism. We utilized the 2012 iteration of the Nationwide Inpatient Sample to identify adult inpatient admissions associated with arrhythmias in patients with isomerism. Data regarding demographics, comorbidities, and various procedures were collected and compared between those with and without isomerism. A total of 6,907,109 admissions were analyzed with a total of 861 being associated isomerism. The frequency of arrhythmias was greater in those with isomerism (20.8 vs. 15.4 %). Those with isomerism were also more five times more likely to undergo invasive electrophysiology studies. Length and cost of hospitalization for patients with arrhythmias also tended to be greater in those with isomerism. Mortality did not differ between the two groups. Arrhythmias are more prevalent in those with isomerism, with a majority of arrhythmias in isomerism being atrial. Those with isomerism and arrhythmias also tended to have greater length and cost of hospitalization.

Publication metadata

Author(s): Loomba RS, Aggarwal S, Gupta N, Buelow M, Alla V, Arora RR, Anderson RH

Publication type: Article

Publication status: Published

Journal: Pediatric Cardiology

Year: 2016

Volume: 37

Issue: 2

Pages: 330-337

Print publication date: 01/02/2016

Online publication date: 19/11/2015

Acceptance date: 07/10/2015

ISSN (print): 0172-0643

ISSN (electronic): 1432-1971

Publisher: Springer


DOI: 10.1007/s00246-015-1281-7


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