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Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci
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In long-term cultures of bone marrow from a patient with acute myeloblastic leukaemia (AML) the leukaemic chromosome marker, which was present in a proportion of the marrow cells even during morphological remission, was not detectable after seven days of culture. After florid relapse of AML, large-scale bone marrow cultures were established while the patient received conditioning with cyclophosphamide and total body irradiation as for an allogeneic bone marrow transplant. Marrow cultured for ten days was reinfused and three and six months later the patient was in clinical remission with a normal karyotype.
Author(s): Chang J, Morgenstern G, Deakin D, Testa NG, Coutinho L, Scarffe JH, Harrison C, Dexter TM
Publication type: Article
Publication status: Published
Journal: The Lancet
Print publication date: 08/02/1986
ISSN (print): 0140-6736
ISSN (electronic): 1474-547X
Publisher: The Lancet Publishing Group
Notes: Case Reports
Research Support, Non-U.S. Gov't
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