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Reconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci

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Abstract

In long-term cultures of bone marrow from a patient with acute myeloblastic leukaemia (AML) the leukaemic chromosome marker, which was present in a proportion of the marrow cells even during morphological remission, was not detectable after seven days of culture. After florid relapse of AML, large-scale bone marrow cultures were established while the patient received conditioning with cyclophosphamide and total body irradiation as for an allogeneic bone marrow transplant. Marrow cultured for ten days was reinfused and three and six months later the patient was in clinical remission with a normal karyotype.

Publication metadata

Author(s): Chang J, Morgenstern G, Deakin D, Testa NG, Coutinho L, Scarffe JH, Harrison C, Dexter TM

Publication type: Article

Publication status: Published

Journal: The Lancet

Year: 1986

Volume: 1

Issue: 8476

Pages: 294-295

Print publication date: 08/02/1986

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(86)90828-7

DOI: 10.1016/S0140-6736(86)90828-7

Notes: Case Reports Journal Article Research Support, Non-U.S. Gov't England

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