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Stereological approaches to dementia research using human brain tissue

Lookup NU author(s): Dr Daniel ErskineORCiD, Dr Ahmad Khundakar


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The relationship between the clinical features of dementia disorders and the resultant changes in underlying neuropathological mechanisms has long been of interest to researchers working in the field of neurodegenerative disorders. The majority of neuropathological research in dementia has utilized semi-quantitative analysis of protein inclusions, which have defined the hallmark histological features of the conditions. However, the advent of three-dimensional stereological techniques has enabled unbiased and fully quantitative assessment of brain tissue. The present review focuses on studies that have used these techniques to elucidate important relationships between neuropathological changes and clinical features and, in doing so, revealed important mechanistic insights into the pathophysiology of dementia disorders.

Publication metadata

Author(s): Erskine D, Khundakar AA

Publication type: Review

Publication status: Published

Journal: Journal of Chemical Neuroanatomy

Year: 2016

Volume: 76

Issue: Part B

Pages: 73–81

Print publication date: 01/10/2016

Online publication date: 14/01/2016

Acceptance date: 12/01/2016

ISSN (print): 0891-0618

ISSN (electronic): 1873-6300


DOI: 10.1016/j.jchemneu.2016.01.004

PubMed id: 26777894