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Lookup NU author(s): Matthew Ainsworth, Professor Marcus Kaiser, Dr Jennifer Simonotto, Professor Miles Whittington
This is the final published version of an article that has been published in its final definitive form by National Academy of Sciences, 2016.
For re-use rights please refer to the publisher's terms and conditions.
Repeated presentations of sensory stimuli generate transient gamma-frequency (30-80 Hz) responses in neocortex that show plasticity in a task-dependent manner. Complex relationships between individual neuronal outputs and the mean, local field potential (population activity) accompany these changes, but little is known about the underlying mechanisms responsible. Here we show that transient stimulation of input layer 4 sufficient to generate gamma oscillations induced two different, lamina-specific plastic processes that correlated with lamina-specific changes in responses to further, repeated stimulation: Unit rates and recruitment showed overall enhancement in supragranular layers and suppression in infragranular layers associated with excitatory or inhibitory synaptic potentiation onto principal cells, respectively. Both synaptic processes were critically dependent on activation of GABA(B) receptors and, together, appeared to temporally segregate the cortical representation. These data suggest that adaptation to repetitive sensory input dramatically alters the spatiotemporal properties of the neocortical response in a manner that may both refine and minimize cortical output simultaneously.
Author(s): Ainsworth M, Lee S, Kaiser M, Simonotto J, Kopell NJ, Whittington MA
Publication type: Article
Publication status: Published
Journal: Proceedings of the National Academy of Sciences of the USA
Year: 2016
Volume: 113
Issue: 19
Pages: E2721-E2729
Print publication date: 10/05/2016
Online publication date: 26/04/2016
Acceptance date: 02/04/2016
Date deposited: 17/03/2017
ISSN (print): 0027-8424
ISSN (electronic): 1091-6490
Publisher: National Academy of Sciences
URL: http://dx.doi.org/10.1073/pnas.1605243113
DOI: 10.1073/pnas.1605243113
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