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Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD

Lookup NU author(s): Professor Helen ReevesORCiD, Marco Zaki, Professor Chris Day


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Hepatocellular carcinoma (HCC) is the second commonest cause of cancer death worldwide. Rather than falling as a result of prevention and treatments for viral hepatitis, an increase is evident in developed nations consequent to the rising prevalence of obesity and type 2 diabetes mellitus (T2DM)-the two major risk factors for nonalcoholic fatty liver disease (NAFLD). The majority of patients with HCC complicating these conditions present with advanced disease as the tools for surveillance are inadequate, and the "at-risk" population is not well characterized. This review will summarize the epidemiological evidence linking obesity, T2DM, and NAFLD with HCC, what is known about the pathogenic mechanisms involved, as well as their relevance for clinicians managing patients at risk. There will also be an overview of the "unmet needs" surrounding this topic, with suggestions for the direction translational research should take in order to prevent progression of NAFLD to HCC, to improve early detection of HCC in those with NAFLD, as well as to improve outcomes for those affected.

Publication metadata

Author(s): Reeves HL, Zaki MYW, Day CP

Publication type: Review

Publication status: Published

Journal: Digestive Diseases and Sciences

Year: 2016

Volume: 61

Issue: 5

Pages: 1234-1245

Print publication date: 01/05/2016

Online publication date: 26/02/2016

Acceptance date: 09/02/2016

ISSN (print): 0163-2116

ISSN (electronic): 1573-2568

Publisher: SPRINGER


DOI: 10.1007/s10620-016-4085-6