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Lookup NU author(s): Professor John LoughlinORCiD
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Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher’s point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the ‘European League Against Rheumatism study group on OA’ and People with Arthritis/ Rheumatism across Europe (PARE) representatives.
Author(s): van-der-Kraan PM, Berenbaum F, Blanco FJ, de-Bari C, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van-Meurs J, Vincent T, Wittoek R, Lories R
Publication type: Article
Publication status: Published
Journal: RMD Open
Year: 2016
Volume: 2
Issue: 1
Print publication date: 06/06/2016
Online publication date: 26/05/2016
Acceptance date: 07/03/2016
ISSN (electronic): 2056-5933
Publisher: BMJ Publishing Group
URL: http://rmdopen.bmj.com/content/2/1/e000224
DOI: 10.1136/rmdopen-2015-000224
PubMed id: 27252894
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