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Translation of clinical problems in osteoarthritis into pathophysiological research goals

Lookup NU author(s): Professor John LoughlinORCiD


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Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher’s point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the ‘European League Against Rheumatism study group on OA’ and People with Arthritis/ Rheumatism across Europe (PARE) representatives.

Publication metadata

Author(s): van-der-Kraan PM, Berenbaum F, Blanco FJ, de-Bari C, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van-Meurs J, Vincent T, Wittoek R, Lories R

Publication type: Article

Publication status: Published

Journal: RMD Open

Year: 2016

Volume: 2

Issue: 1

Print publication date: 06/06/2016

Online publication date: 26/05/2016

Acceptance date: 07/03/2016

ISSN (electronic): 2056-5933

Publisher: BMJ Publishing Group


DOI: 10.1136/rmdopen-2015-000224

PubMed id: 27252894


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