Jack Roberts Olivia Boldvig Guillaume Aubourg Sai Kanchenapally Professor David Deehan et al. | Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence | 2024 |
|
Professor John Loughlin
| Three decades of osteoarthritis molecular genetics research: From early discussions to impressive breakthroughs | 2024 |
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Dr Paweł Widera Dr Samuel Danso Professor John Loughlin Professor Jaume Bacardit
| Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials | 2023 |
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Dr Sarah Rice Abby Brumwell Julia Falk Yulia Kehayova John Casement et al. | Genetic risk of osteoarthritis operates during human skeletogenesis | 2023 |
|
Yulia Kehayova Dr Sarah Rice Professor John Loughlin
| Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk–Conferring Alleles on a Shared Target Gene, COLGALT2 | 2023 |
|
Yulia Kehayova Dr Sarah Rice Professor John Loughlin
| Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues | 2023 |
|
Guillaume Aubourg Dr Sarah Rice Professor John Loughlin
| Genetics of osteoarthritis | 2022 |
|
Abby Brumwell Guillaume Aubourg Juhel Hussain Chowdhery Dr Eleanor Parker Professor David Deehan et al. | Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk | 2022 |
|
Professor John Loughlin Dr Paweł Widera Professor Jaume Bacardit
| Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort | 2022 |
|
Professor John Loughlin
| Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method | 2022 |
|
Professor John Loughlin
| Towards precision medicine – is genetic risk prediction ready for prime time in osteoarthritis? | 2022 |
|
Professor John Loughlin
| Translating osteoarthritis genetics research: challenging times ahead | 2022 |
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Dr Sarah Rice Jack Roberts Maria Tselepi Abby Brumwell Professor John Loughlin et al. | Genetic and Epigenetic Fine-Tuning of TGFB1 Expression Within the Human Osteoarthritic Joint | 2021 |
|
Yulia Kehayova Professor John Loughlin Dr Sarah Rice
| Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis | 2021 |
|
Dr Sarah Rice Kat Cheung Professor John Loughlin
| Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene | 2021 |
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Dr Sarah Rice Dr Sami Anjum Professor David Deehan Professor John Loughlin
| Multi‐Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility | 2021 |
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Professor John Loughlin
| Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping | 2021 |
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Professor John Loughlin
| Osteoarthritis Research Society International (OARSI): Past, present and future | 2021 |
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Professor John Loughlin
| Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers | 2020 |
|
Dr Sarah Rice Professor David Young Professor John Loughlin
| Interplay between genetics and epigenetics in osteoarthritis | 2020 |
|
Dr Paweł Widera Professor John Loughlin Professor Jaume Bacardit
| Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data | 2020 |
|
Dr Tony Sorial Ines Hofer Maria Tselepi Kat Cheung Dr Eleanor Parker et al. | Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC | 2020 |
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Professor John Loughlin
| The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach | 2020 |
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Dr Sarah Rice Kat Cheung Dr Louise Reynard Professor John Loughlin
| Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals | 2019 |
|
Professor John Loughlin
| Erratum: Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures (Nature communications (2019) 10 1 (2054)) | 2019 |
|
Dr Colin Shepherd Abi Reese Dr Louise Reynard Professor John Loughlin
| Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP | 2019 |
|
Dr Sarah Rice Dr Colin Shepherd Professor John Loughlin
| Functional testing of thousands of osteoarthritis-associated variants for regulatory activity | 2019 |
|
Professor John Loughlin
| GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures | 2019 |
|
Dr Sarah Rice Kat Cheung Dr Louise Reynard Professor John Loughlin
| Identification and analysis of novel methylation quantitative trait loci (mQTLs) in osteoarthritis | 2019 |
|
Dr Sarah Rice Maria Tselepi Dr Tony Sorial Guillaume Aubourg Dr Colin Shepherd et al. | Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci | 2019 |
|
Dr Colin Shepherd Dr Dongxing Zhu Andrew Skelton Dr Louise Reynard Professor John Loughlin et al. | Functional characterization of the osteoarthritis genetic risk residing at ALDH1A2 identifies rs12915901 as a key target variant. | 2018 |
|
Dr Madhushika Ratnayake Maria Tselepi Professor John Loughlin
| Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5 | 2018 |
|
Dr Colin Shepherd Dr Louise Reynard Professor John Loughlin
| Genotype at the MGP OA risk locus correlates with an expression quantitative trait locus operating on MGP in cartilage and with DNA methylation at a cluster of regulatory CpGs within ARHGDIB | 2018 |
|
Dr Sarah Rice Guillaume Aubourg Dr Tony Sorial Dr David Almarza Gomez Maria Tselepi et al. | Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk | 2018 |
|
Dr Sarah Rice Dr Tony Sorial Guillaume Aubourg Dr Colin Shepherd Maria Tselepi et al. | Identification of novel methylation quantitative trait loci (mqtls) and functional characterization using CRISPR/CAS9 and gene expression analysis prioritizes PLEC as an OA risk gene | 2018 |
|
Dr Madhushika Ratnayake Maria Tselepi Dr Louise Reynard Professor John Loughlin
| A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5 | 2017 |
|
Dr Sarah Rice Guillaume Aubourg Dr Tony Sorial Professor David Deehan Professor John Loughlin et al. | Epigenetic and transcriptional effects operate on the SUPT3H and RUNX2 genes residing at the chromosome 6p21.1 osteoarthritis susceptibility locus and correlate with the association signal | 2017 |
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Dr Colin Shepherd Dr Dongxing Zhu Andrew Skelton Dr Louise Reynard Professor John Loughlin et al. | Functional characterisation of the osteoarthritis genetic risk locus that resides at the gene ALDH1A2, coding for the retinoic acid synthesis enzyme RALDH2, identifies rs4646636 and rs12915901 as key target SNPs | 2017 |
|
Dr David Almarza Gomez Professor John Loughlin
| Genome editing for human osteoarthritis - a perspective | 2017 |
|
Dr Louise Reynard Andrew Skelton David Young Professor John Loughlin
| The first international workshop on the epigenetics of osteoarthritis | 2017 |
|
Dr Louise Reynard Dr Amanda Villalvilla Garcia Professor John Loughlin
| Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis | 2017 |
|
Professor John Loughlin Dr Carole Proctor
| A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells | 2016 |
|
Dr Michael Rushton Professor John Loughlin Dr Carole Proctor
| Age-related Changes in Mesenchymal Stem Cells Identified Using a Multi-omics Approach | 2016 |
|
Andrew Skelton Dr Rodolfo Gomez Professor John Loughlin Dr Louise Reynard
| Age-related DNA methylation changes in normal and osteoarthritis cartilage | 2016 |
|
Michael Rushton Professor John Loughlin Dr Carole Proctor
| Decoding the regulatory landscape of ageing in musculoskeletal engineered tissues using genome-wide DNA methylation and RNASeq | 2016 |
|
Maria Tselepi Madhushika Ratnayake Dr Louise Reynard Professor John Loughlin
| Differences in the response of mesenchymal stem cells from healthy donors and OA patients to exogenous GDF5 during chondrogenic differentiation | 2016 |
|
Dr Amanda Villalvilla Garcia Dr Fiona Gee Professor John Loughlin Dr Louise Reynard
| DNA methylation in the 20q13 OA susceptibility region marked by rs6094710 is associated with modulation of NCOA3 gene expression | 2016 |
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Dr Colin Shepherd Andrew Skelton Dr Michael Rushton Dr Louise Reynard Professor John Loughlin et al. | Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874 | 2016 |
|
Dr Louise Reynard Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin
| Functional characterization of the osteoarthritis susceptibility mapping to CHST11 - a bioinformatics and molecular study | 2016 |
|
Emma Rogers Dr Louise Reynard Dr Kenneth Rankin Professor John Loughlin
| Functional Investigation of an OA susceptibility locus at chromsome 9q33.1 associated with female hip osteoarthritis | 2016 |
|
Dr Louise Reynard Professor John Loughlin
| Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells | 2016 |
|
Professor John Loughlin
| Translation of clinical problems in osteoarthritis into pathophysiological research goals | 2016 |
|
Dr Fiona Gee Dr Michael Rushton Professor John Loughlin Dr Louise Reynard
| Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs116855380 | 2015 |
|
Fabio D'agostino Professor John Loughlin
| Development of successful bio-preservation strategies for cell therapy medicinal products | 2015 |
|
Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard
| Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients | 2015 |
|
Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard
| Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients | 2015 |
|
Dr Colin Shepherd Andrew Skelton Dr Michael Rushton Dr Louise Reynard Professor John Loughlin et al. | Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874 | 2015 |
|
Dr Katherine Johnson Dr Louise Reynard Professor John Loughlin
| Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591 | 2015 |
|
Professor John Loughlin
| Genetic contribution to osteoarthritis development: current state of evidence | 2015 |
|
Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Rebecca Darlay et al. | Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci | 2015 |
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Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Fiona Gee et al. | Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk | 2015 |
|
Professor John Loughlin Dr Louise Reynard
| Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA | 2015 |
|
Professor John Loughlin Dr Louise Reynard
| Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA | 2015 |
|
Dr Louise Reynard Professor John Loughlin
| The carbohydrate sulfotransferase gene CHST11 is regulated by DNA methylation which impacts on the functional effect of the OA generic susceptibility residing at this locus | 2015 |
|
Emma Rogers Dr Louise Reynard Professor John Loughlin
| The role of inflammation-related genes in osteoarthritis | 2015 |
|
Steffan Bos Professor Fraser Birrell Professor Andrew McCaskie Michael Reed Professor John Loughlin et al. | A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip | 2014 |
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Dr Fiona Gee Clare Clubbs Dr Emma Raine Dr Louise Reynard Professor John Loughlin et al. | Allelic expression analysis of genes from within the osteoarthritis susceptibility locus at chromosome 3p21 reveals functional gene expression effects at GNL3 and SPCS1 that correlate with the association signal | 2014 |
|
Dr Fiona Gee Clare Clubbs Emma Raine Dr Louise Reynard Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 | 2014 |
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Dr Fiona Gee Clare Clubbs Dr Emma Raine Dr Louise Reynard Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 | 2014 |
|
Professor Andrew McCaskie Professor John Loughlin
| Assessment of osteoarthritis candidate genes in a meta-analysis of 9 genome-wide association studies | 2014 |
|
Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Dr Kenneth Rankin Professor David Young et al. | Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis | 2014 |
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Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Ramsay Refaie Dr Kenneth Rankin et al. | Characterization of the cartilage DNA methylome in knee and hip osteoarthritis | 2014 |
|
Dr Louise Reynard Dr Catherine Bui Catherine Syddall Professor John Loughlin
| CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383 | 2014 |
|
Emma Rogers Dr Louise Reynard Dr Kate Rennie Professor John Loughlin
| Expression analysis of osteoarthritis associated genes in mesenchymal stem cells differentiating into joint-associated cells | 2014 |
|
Dr Katherine Johnson Dr Louise Reynard Professor John Loughlin
| Functional analysis of the osteoarthritis susceptibility locus marked by the polymorphism rs10492367 | 2014 |
|
Dr Louise Reynard Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin
| Functional analysis of the osteoarthritis susceptibility locus residing at the carbohydrate sulfotransferase 11 gene CHST11 | 2014 |
|
Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin
| Human Chondrocytes Respond Discordantly to the Protein Encoded by the Osteoarthritis Susceptibility Gene GDF5 | 2014 |
|
Emma Raine Dr Louise Reynard Professor John Loughlin
| Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome | 2014 |
|
Dr Emma Raine Dr Louise Reynard Professor John Loughlin
| Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome | 2014 |
|
Professor John Loughlin
| New functional microsatellite associated with osteoarthritis susceptibility | 2014 |
|
Dr Michael Rushton Dr Fiona Gee Dr Louise Reynard Professor John Loughlin
| The osteoarthritis association marked by SNP rs6094710 mediates its effect by reducing the expression of NCOA3 in joint tissues | 2014 |
|
Andrew Dodd Catherine Syddall Professor John Loughlin
| A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression | 2013 |
|
Dr Emma Raine Andrew Dodd Dr Louise Reynard Professor John Loughlin
| Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues | 2013 |
|
Professor John Loughlin Professor Andrew McCaskie
| Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data | 2013 |
|
Dr Louise Reynard Professor John Loughlin
| Insights from human genetic studies into the pathways involved in osteoarthritis | 2013 |
|
Professor Gavin Hudson Dr Ian Wilson Professor Fraser Birrell Professor Andrew McCaskie Professor John Loughlin et al. | No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls | 2013 |
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Professor John Loughlin
| The Epigenetic Influences in Osteoarthritis | 2013 |
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Dr Louise Reynard Professor John Loughlin
| The genetics and functional analysis of primary osteoarthritis susceptibility | 2013 |
|
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin
| The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383 | 2013 |
|
Andrew Dodd Professor John Loughlin
| A functional investigation of a rare variant in the promoter of the OA-associated locus GDF5 and the discovery of a trans-acting factor interacting with the variant site | 2012 |
|
Professor Rita Horvath Vivienne Neeve Dr Angela Pyle Dr Helen Griffin Deepthi Ashok et al. | A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy | 2012 |
|
Andrew Dodd Dr Emma Raine Dr Louise Reynard Professor John Loughlin
| Allelic expression analysis in patient issues of the osteoarthritis and of the lumbar disc herniation susceptibility loci that map to COL11A1 | 2012 |
|
Dr Madhushika Ratnayake Dr Louise Reynard Dr Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3 | 2012 |
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Dr Madhushika Ratnayake Dr Louise Reynard Dr Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3 | 2012 |
|
Dr Madhushika Ratnayake Dr Louise Reynard Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3 | 2012 |
|
Dr Emma Raine Dr Louise Reynard Professor John Loughlin
| Allelic expression analysis, and association with OA, of common variants in SMAD3 | 2012 |
|
Dr Mauro Santibanez Koref Professor John Loughlin
| An investigation of the effect of exogenous growth factor GDF5 on primary OA chondrocytes - is there a predictable response? | 2012 |
|
Professor John Loughlin
| Association of a BMP5 microsatellite with knee osteoarthritis: case-control study | 2012 |
|
Professor John Loughlin
| Association of a BMP5 microsatellite with knee osteoarthritis | 2012 |
|
Professor Sophie Hambleton Dr David McDonald Dr Helen Griffin Angela Grainger Dr Louise Reynard et al. | Autosomal recessive combines immunodeficiency due to loss of function mutation in Tripeptidyl Peptidase II | 2012 |
|
Dr Louise Reynard Professor John Loughlin
| Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22 | 2012 |
|
Dr Emma Raine Andrew Dodd Dr Louise Reynard Professor John Loughlin
| Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22 | 2012 |
|
Dr Louise Reynard Professor John Loughlin
| Genetics and epigenetics of osteoarthritis | 2012 |
|
Dr Madhushika Ratnayake Sheryl Mitchell Michael Reed Professor Andrew McCaskie Professor John Loughlin et al. | Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study | 2012 |
|
Dr Emma Raine Professor Fraser Birrell Professor Andrew McCaskie Professor John Loughlin
| Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study | 2012 |
|
Yaobo Xu Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan et al. | Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA | 2012 |
|
Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan Dr Mauro Santibanez Koref et al. | Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA | 2012 |
|
Steffan Bos Dr Emma Raine Professor John Loughlin
| Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues | 2012 |
|
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin
| The identification of the trans-acting factors that differentially regulate the expression of GDF5 via the OA associated SNP rs143383 | 2012 |
|
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin
| The identification of trans-acting factors that differentially regulate the expression of GDF5 via the osteoarthritis associated SNP RS143383 | 2012 |
|
Dr Louise Reynard Catherine Syddall Professor John Loughlin
| The osteoarthritis susceptibility gene GDF5 is under epigenetic regulation by DNA methylation - the molecular interplay between genetics and epigenetics in disease risk | 2012 |
|
Dr Helen Griffin Dr David McDonald Dr Rachel Dickinson Angela Grainger Dr Louise Reynard et al. | Whole exome sequencing as a diagnostic tool in primary immunodeficiency | 2012 |
|
Professor John Loughlin Professor Andrew McCaskie
| A variant in MCF2L is associated with osteoarthritis | 2011 |
|
Andrew Dodd Dr Louise Reynard Professor John Loughlin
| Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus | 2011 |
|
Dr Rachel Dickinson Dr Helen Griffin Dr Venetia Bigley Dr Louise Reynard Raf Hussain et al. | Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency | 2011 |
|
Dr Louise Reynard Dr Catherine Bui Professor David Young Professor John Loughlin
| Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation | 2011 |
|
Professor John Loughlin
| Genetic indicators and susceptibility to osteoarthritis | 2011 |
|
Professor John Loughlin
| Genetics of osteoarthritis | 2011 |
|
Professor Andrew McCaskie Professor John Loughlin
| Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study | 2011 |
|
Professor John Loughlin
| Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip - an emerging genetic overlap | 2011 |
|
Steffan Bos Dr Kaye Chapman Professor John Loughlin
| Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility | 2011 |
|
Professor John Loughlin Professor Andrew McCaskie
| Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 | 2011 |
|
Professor John Loughlin
| Osteoarthritis year 2010 in review: genetics | 2011 |
|
Professor John Loughlin
| Osteoarthritis: All types of trouble-defining OA in the genomic era | 2011 |
|
Professor John Loughlin
| Summary of the OA biomarkers workshop 2010 – genetics and genomics: new targets in OA | 2011 |
|
Professor John Loughlin Professor Andrew McCaskie
| The effect of genome-wide association scan quality control on imputation outcome for common variants | 2011 |
|
Dr David McDonald Dr Helen Griffin Angela Grainger Dr Louise Reynard Professor John Loughlin et al. | Whole-exome deep sequencing identifies a novel causative mutation in primary immunodeficiency | 2011 |
|
Professor John Loughlin
| A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis [Bone, 44S2 (2009) S224] [erratum] | 2010 |
|
Professor John Loughlin
| A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 | 2010 |
|
Athanasia Gravani Dr Emma Raine Andrew Dodd Professor John Loughlin
| A multicenter study of the association of aromatase and estrogen receptor genes with hip and knee osteoarthritis | 2010 |
|
Dr Emma Raine Athanasia Gravani Professor John Loughlin
| Allelic expression analysis of the genes within the chromosome 7q22 OA suceptibility locus reveals evidence for functional polymorphism in COGS | 2010 |
|
Professor John Loughlin
| BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model | 2010 |
|
Professor John Loughlin
| Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis | 2010 |
|
Athanasia Gravani Dr Emma Raine Andrew Dodd Professor John Loughlin
| Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study | 2010 |
|
Andrew Dodd Professor John Loughlin
| Deep sequencing of gdfs in over 1900 osteoarthritis cases and controls reveal novel and potentially functional rare variants in the protein coding and promoter regions of the gene | 2010 |
|
Steffan Bos Professor John Loughlin
| Functional characterization of OA risk polymorphism RS225014 at DI02 in human OA cartilage | 2010 |
|
Professor John Loughlin
| Identification and characterization of novel parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutations in eight families with autosomal recessive hypoparathyroidism | 2010 |
|
Dr Kaye Chapman Professor John Loughlin
| Interleukin-1 region meta-analysis with osteoarthritis phenotypes | 2010 |
|
Professor Andrew McCaskie Professor John Loughlin
| The Arcogen Consortium: Stage 1 of a genome-wide association scan for osteoarthritis | 2010 |
|
Dr Louise Reynard Athanasia Gravani Professor John Loughlin
| The osteoarthritis-associated gene GDF5 is under epigenetic regulation in patient tissues and in a range of human cell lines | 2010 |
|
Professor John Loughlin
| A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis | 2009 |
|
Professor John Loughlin
| Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis | 2009 |
|
Professor John Loughlin
| Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes | 2009 |
|
Dr Kaye Chapman Professor John Loughlin
| Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism | 2009 |
|
Professor John Loughlin
| Genetics and osteoarthritis: implications for the clinic | 2009 |
|
Karen Chapman Dr Masahiro Nakajima Professor John Loughlin
| Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations | 2009 |
|
Professor John Loughlin Steffan Bos
| Large-scale analysis of association between GDF5 (rs143383) and FRZB (rs7775 and rs288326) variants and hip, knee and hand osteoarthritis | 2009 |
|
Dr Kaye Chapman Professor John Loughlin
| Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand | 2009 |
|
Professor John Loughlin
| Testing the druggable EDG2 knee OA genetic factor for replication in a wide range of sample collections | 2009 |
|
Professor John Loughlin
| The role of genetic susceptibility in osteoarthritis development | 2009 |
|
Dr Kaye Chapman Arata Takahashi Dr Catherine Watson Professor John Loughlin
| A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility | 2008 |
|
Professor John Loughlin Dr Kaye Chapman
| Big is beautiful | 2008 |
|
Professor John Loughlin
| Genetic associations in peripheral joint osteoarthritis and spinal degenerative disease: a systematic review | 2008 |
|
Professor John Loughlin
| Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis | 2008 |
|
Professor John Loughlin
| Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis | 2008 |
|
Steffan Bos Dr Mitsushiro Nakatomi Professor John Loughlin
| Identification of DIO2 as new susceptibility locus for symptomatic Osteoarthritis | 2008 |
|
Professor John Loughlin
| Novel mutations in exon 2 of MATN3 affect residues within the alpha-helices of the A-domain and can result in the intracellular retention of mutant matrilin-3 | 2008 |
|
Professor John Loughlin
| Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility | 2007 |
|
Professor John Loughlin
| An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage | 2007 |
|
Professor John Loughlin
| Extreme context specificity in differential allelic expression | 2007 |
|
Professor John Loughlin
| Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus | 2007 |
|
Professor John Loughlin
| Genetic association analysis of RHOB and TXNDC3 in osteoarthritis | 2007 |
|
Professor John Loughlin
| Meta-analysis of association between the ASPN D-repeat and osteoarthritis | 2007 |
|
Professor John Loughlin
| Osteoarthritis genetics: current status and future prospects | 2007 |
|
Professor John Loughlin Dr Kaye Chapman
| Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee | 2007 |
|
Professor John Loughlin
| Variation in the secreted frizzled-related protein-3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty | 2007 |
|
Professor John Loughlin
| Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci | 2006 |
|
Dr Kaye Chapman Professor John Loughlin
| Association of the interleukin-1 gene cluster with osteoarthritis of the hip: comment on the article by Meulenbelt et al and the letter by Smith et al | 2006 |
|
Professor John Loughlin
| Osteoarthritis linkage scan: more loci for the geneticists to investigate | 2006 |
|
Dr Kaye Chapman Professor John Loughlin
| Presence of a primary hip osteoarthritis susceptibility locus on chromosome 6: comment on the article by Meenagh et al | 2006 |
|
Professor John Loughlin
| Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women | 2006 |
|
Professor John Loughlin Dr Kaye Chapman
| The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population | 2006 |
|
Professor John Loughlin
| Crystals in hand | 2005 |
|
Professor John Loughlin
| Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q | 2005 |
|
Professor John Loughlin
| Genetic background increases the risk of hip osteoarthritis | 2005 |
|
Professor John Loughlin
| Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population | 2005 |
|
Professor John Loughlin
| Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting | 2005 |
|
Professor John Loughlin
| Recent advances in the genetic investigation of osteoarthritis | 2005 |
|
Professor John Loughlin
| The common HFE variants C282Y and H63D are not associated with primary OA of the hip or knee | 2005 |
|
Professor John Loughlin
| The genetic epidemiology of human primary osteoarthritis: current status | 2005 |
|
Professor John Loughlin
| Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis | 2004 |
|
Professor John Loughlin
| Familial inheritance of osteoarthritis: documented family subsets | 2004 |
|
Dr Kaye Chapman Professor John Loughlin
| Finer linkage mapping of primary osteoarthritis susceptibility loci on chromosomes 4 and 16 in families with affected women | 2004 |
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Professor John Loughlin
| Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females | 2004 |
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Professor John Loughlin
| Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13 | 2004 |
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Professor John Loughlin
| Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women | 2003 |
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Professor John Loughlin
| Genetic association analysis of BMP5 as a potential osteoarthritis susceptibility gene | 2003 |
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Professor John Loughlin
| Genetics of osteoarthritis and potential for drug development | 2003 |
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Professor John Loughlin
| A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression | 2002 |
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Professor John Loughlin
| Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis | 2002 |
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Professor John Loughlin
| Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6 | 2002 |
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Professor John Loughlin
| Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs | 2002 |
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Professor John Loughlin
| Genome studies and linkage in primary osteoarthritis | 2002 |
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Professor John Loughlin
| Refined linkage mapping of a hip osteoarthritis susceptibility locus on chromosome 2q | 2002 |
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Professor John Loughlin
| Genetic epidemiology of primary osteoarthritis | 2001 |
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Dr Kaye Chapman Professor John Loughlin
| Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia | 2001 |
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Professor Michael Briggs Professor John Loughlin
| Mutations in the vWFA domain of matrilin-3 cause multiple epiphyseal dysplasia | 2001 |
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Professor John Loughlin
| Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: comment on the article by Meulenbelt et al | 2000 |
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Professor John Loughlin Dr Kaye Chapman
| Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis | 2000 |
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Professor John Loughlin
| Germline and somatic mosaicism in achondroplasia | 2000 |
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Dr Kaye Chapman Professor John Loughlin
| Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis | 2000 |
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Professor John Loughlin Dr Kaye Chapman
| Linkage analysis of chromosome 2q in osteoarthritis | 2000 |
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Professor John Loughlin
| Brachydactyly Type B: Linkage to Chromosome 9q22 and Evidence for Genetic Heterogeneity | 1999 |
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Professor John Loughlin Professor Michael Briggs
| Identification of novel pro-alpha 2(IX) collagen gene mutations in two families with distinctive olgo-epiphyseal forms of multiple epiphyseal dysplasia | 1999 |
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Professor John Loughlin
| Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage | 1999 |
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Professor John Loughlin
| Stratification analysis of an osteoarthritis genome screen-suggestive linkage to chromosomes 4, 6, and 16 | 1999 |
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Professor John Loughlin
| European Y-chromosomal lineages in Polynesians: a contrast to the population structure revealed by mtDNA | 1998 |
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Professor John Loughlin
| Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia | 1998 |
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Professor John Loughlin
| Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome | 1998 |
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Professor John Loughlin
| Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis | 1997 |
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Professor John Loughlin
| Genetic influences on osteoarthritis in women: a twin study | 1996 |
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Professor John Loughlin
| Differential allelic expression of the type II collagen gene (COL2A1) in osteoarthritic cartilage | 1995 |
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Professor John Loughlin
| Linkage of the gene that encodes the alpha 1 chain of type V collagen (COL5A1) to type II Ehlers-Danlos syndrome (EDS II) | 1995 |
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Professor John Loughlin
| Exclusion of the cartilage link protein and the cartilage matrix protein genes as the mutant loci in several heritable chondrodysplasias | 1994 |
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Professor John Loughlin
| Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene | 1994 |
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Professor John Loughlin
| Mutation screening by a combination of biotin-SSCP and direct sequencing | 1994 |
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Professor John Loughlin
| Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein | 1994 |
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