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Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease

Lookup NU author(s): Professor Quentin AnsteeORCiD, Professor Chris Day


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Genome-wide association studies and candidate gene studies have informed our understanding of factors contributing to the well-recognized interindividual variation in the progression and outcomes of alcoholic liver disease and nonalcoholic fatty liver disease. We discuss the mounting evidence for shared modifiers and common pathophysiological processes that contribute to development of both diseases. We discuss the functions of proteins encoded by risk variants of genes including patatin-like phospholipase domain-containing 3 and transmembrane 6 superfamily member 2, as well as epigenetic factors that contribute to the pathogenesis of alcoholic liver disease and nonalcoholic fatty liver disease. We also discuss important areas of future genetic research and their potential to affect clinical management of patients.

Publication metadata

Author(s): Anstee QM, Seth D, Day CP

Publication type: Article

Publication status: Published

Journal: Gastroenterology

Year: 2016

Volume: 150

Issue: 8

Pages: 1728-1744.e7

Print publication date: 01/06/2016

Online publication date: 10/02/2016

Acceptance date: 20/01/2016

ISSN (print): 0016-5085

ISSN (electronic): 1528-0012

Publisher: W.B Saunders Co.


DOI: 10.1053/j.gastro.2016.01.037


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Funder referenceFunder name
Higher Education Funding Council for England
National Institute on Alcohol Abuse and Alcoholism
634413European Union
UO1 AA018389-01National Institutes of Health