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The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

Lookup NU author(s): Dr Lee Borthwick

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Abstract

The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 targeted therapies have been successfully employed to treat a range of inflammatory conditions such as rheumatoid arthritis and gouty arthritis. This review will introduce the members of the IL-1 cytokine family, briefly discuss the cellular origins and cellular targets and provide an overview of the role of these molecules in inflammation and fibrosis in the lung.

Publication metadata

Author(s): Borthwick LA

Publication type: Review

Publication status: Published

Journal: Seminars in Immunopathology

Year: 2016

Volume: 38

Issue: 4

Pages: 517-534

Print publication date: 01/07/2016

Online publication date: 21/03/2016

Acceptance date: 25/02/2016

ISSN (print): 1863-2297

ISSN (electronic): 1863-2300

Publisher: SPRINGER HEIDELBERG

URL: http://dx.doi.org/10.1007/s00281-016-0559-z

DOI: 10.1007/s00281-016-0559-z

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