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Browsing publications by Dr Lee Borthwick.

Newcastle AuthorsTitleYearFull text
Dr Lee Borthwick
Professor Andrew Fisher
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection2022
Dr Morvern Morrison
Dr Anders Andreasson
Catriona Charlton
Dr Alisha Chhatwal
Dr Bill Scott
et al.
Transcriptional analysis identifies potential novel biomarkers associated with successful ex-vivo perfusion of human donor lungs2022
Dr Jack Leslie
Hannah Paish
Amy Collins
Rebecca Scott
Abi Watson
et al.
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis2021
JinHeng Lin
Professor Michael Taggart
Dr Lee Borthwick
Professor Andrew Fisher
Dr Malcolm Brodlie
et al.
Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells2021
Dr Lee Borthwick
Ben Barksby
Rachel Burgoyne
Rory Barnes
Professor Andrew Fisher
et al.
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease2021
Rachel Burgoyne
Professor Andrew Fisher
Dr Lee Borthwick
The role of epithelial damage in the pulmonary immune response2021
Dr Julie Worrell
Dr Jack Leslie
Dr Graham Smith
Marco Zaki
Hannah Paish
et al.
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis2020
Dr Jack Leslie
Dr Marina Garcia Macia
Dr Saimir Luli
Dr Julie Worrell
William Reilly
et al.
c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis2020
Dr Jack Leslie
Benjamin Millar
Alicia Del Carpio Pons
Rachel Burgoyne
Joseph Frost
et al.
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis2020
Ben Barksby
Dr Lee Borthwick
Pellino-1 Regulates the Responses of the Airway to Viral Infection2020
Professor Derek Mann
Dr Lee Borthwick
Professor David Deehan
Dr Nicholas Kalson
Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI2020
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Professor Fiona Oakley
Dr Lee Borthwick
et al.
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse2020
Dr Lee Borthwick
Professor Andrew Fisher
The circadian clock protein REVERBα inhibits pulmonary fibrosis development2020
Dr Lee Borthwick
Ben Barksby
Rachel Burgoyne
Rory Barnes
Professor Andrew Fisher
et al.
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis2020
Hannah Paish
Lee Reed
Helen Brown
Mark Bryan
Dr Olivier Govaere
et al.
A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices2019
Hannah Paish
Dr Colin Gillespie
Alicia Del Carpio Pons
Professor Derek Mann
Professor David Deehan
et al.
Chronic, Active Inflammation in Patients with Failed Total Knee Replacements Undergoing Revision Surgery2019
Professor Fiona Oakley
Lucy Gee
Professor Neil Sheerin
Dr Lee Borthwick
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy2019
Hannah Paish
Dr Nicholas Kalson
Dr Graham Smith
Alicia Del Carpio Pons
Nicholas Smith
et al.
Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 22018
Dr Nicholas Kalson
Timothy Brock
Professor Derek Mann
Dr Lee Borthwick
Professor David Deehan
et al.
Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis2018
Dr Sonya Carnell
Dr John Perry
Dr Lee Borthwick
Dr Daniela Vollmer
Dr Jacob Biboy
et al.
Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: A cautionary tale2018
Dr Caroline Wilson
Professor Derek Mann
Dr Lee Borthwick
Epigenetic reprogramming in liver fibrosis and cancer2017
Anders Andreasson
Danai Karamanou
Dr Colin Gillespie
Kasim Jiwa
Dr Nicola Green
et al.
Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion2017
Anders Andreasson
Dr Lee Borthwick
Dr Colin Gillespie
Kasim Jiwa
Jonathan Scott
et al.
The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion2017
Dr Lee Borthwick
Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β2017
Dr Lee Borthwick
Wona Suwara
Dr Sonya Carnell
Dr Nicola Green
Dr Rahul Mahida
et al.
Pseudomonas aeruginosa induced Airway Epithelial Injury Drives Fibroblast Activation: A Mechanism in Chronic Lung Allograft Dysfunction2016
Dr Lee Borthwick
Acidic chitinase primes the protective immune response to gastrointestinal nematodes2016
Dr Lee Borthwick
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis2016
Dr Nicholas Kalson
Dr Lee Borthwick
Professor Derek Mann
Professor David Deehan
International consensus on the definition and classification of fibrosis of the knee joint2016
Dr Lee Borthwick
Professor Andrew Fisher
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis2016
Dr Lee Borthwick
Professor Derek Mann
Osteopontin and HMGB1: novel regulators of HSC activation2016
Kasim Jiwa
Dr Lee Borthwick
Dr Anders Andreasson
Professor John Dark
Professor Andrew Fisher
et al.
Potential therapeutic benefits of the human amniotic epithelium cell secretome during ex-vivo perfusion of donor lungs2016
Dr Lee Borthwick
Professor Andrew Fisher
Professor Christopher Buckley
Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis2016
Dr Lee Borthwick
Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A2016
Dr Lee Borthwick
The IL-1 cytokine family and its role in inflammation and fibrosis in the lung2016
Dr Anders Andreasson
Danai Karamanou
Dr Colin Gillespie
Dr Lee Borthwick
Kasim Jiwa
et al.
Treating Donor Lung Inflammation by Blocking Interleukin-1B-An In Vitro Therapy Testing Platform for Ex Vivo Lung Perfusion2016
David Dixon
Jonathon Coates
Joanna Horabin
Andrew Walker
Dr Nicole Abdul
et al.
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty2015
Dr Nicole Abdul
David Dixon
Andrew Walker
Joanna Horabin
Professor David Deehan
et al.
Fibrosis is a common outcome following total knee arthroplasty2015
Dr Stephen Ball
Monika Suwara
Dr Lee Borthwick
Emerita Professor Janet Wilson
Professor Derek Mann
et al.
How Reliable are Sino-Nasal Cell Lines for Studying the Pathophysiology of Chronic Rhinosinusitis?2015
Dr Lee Borthwick
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma2015
Wona Suwara
Dr Nicola Green
Dr Lee Borthwick
Professor Jelena Mann
Emeritus Professor Nick Europe-Finner
et al.
IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts2014
Dr Lee Borthwick
Incomplete Deletion of IL-4R alpha by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis2014
Monika Suwara
Dr Bart Vanaudenaerde
Dr Nicola Green
Professor Christopher Ward
Dr Lee Borthwick
et al.
Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation2014
Dr Lee Borthwick
Professor Andrew Fisher
TNF- α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction2014
Dr Lee Borthwick
Professor Andrew Fisher
Cytokine mediated tissue fibrosis2013
Dr Lindsay Murphy
Dr Saimir Luli
Dr Lee Borthwick
Dr Steven O'Reilly
Professor Neil Perkins
et al.
Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response2013
Dr Lee Borthwick
Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation2013
Dr Lee Borthwick
Emeritus Professor Nick Europe-Finner
Dr Rahul Mahida
Andrew Walker
Aaron Gardner
et al.
TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis2013
Marta Gorowiec
Dr Lee Borthwick
Dr Sean Parker
Professor John Kirby
Dr Gabriele Saretzki
et al.
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism2012
Wona Suwara
Dr Lee Borthwick
Dr Rahul Mahida
Dr Nicola Green
Aaron Gardner
et al.
Interleukin-1 Alpha (IL-1α) Released from Injured Lung Epithelium is a Critical Alarmin Driving Activation of a Potent Inflammatory Phenotype in Lung Fibroblasts2012
Dr Nicola Green
Wona Suwara
Dr Lee Borthwick
Professor Derek Mann
Professor Andrew Fisher
et al.
Interleukin-33 in Chronic Lung Disease2012
Dr Aaron Ions Gardner
Professor Andrew Fisher
Christine Richter
Grace Johnson
Dr Elizabeth Moisey
et al.
The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation2012
Dr Lee Borthwick
Aaron Gardner
Professor Anthony De Soyza
Professor Derek Mann
Professor Andrew Fisher
et al.
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways2012
Dr Lee Borthwick
Dr Aaron Ions Gardner
Professor Anthony De Soyza
Professor Derek Mann
Professor Andrew Fisher
et al.
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways2012
Dr Lee Borthwick
Dr John Perry
Dr Malcolm Brodlie
Professor Christopher Ward
Katherine Gould
et al.
Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway2011
Dr Rahul Mahida
Monika Suwara
Dr Gavin Johnson
Professor Derek Mann
Emeritus Professor Nick Europe-Finner
et al.
Alarmins in bronchiolitis obliterans syndrome after lung transplantation2011
Dr Lee Borthwick
Phil Botha
Dr Malcolm Brodlie
Aaron Gardner
Dr David Bourn
et al.
Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?2011
Monika Suwara
Dr Rahul Mahida
Dr Lee Borthwick
Professor Jelena Mann
Emeritus Professor Nick Europe-Finner
et al.
The Epithelial Alarmin, Interleukin 1 alpha (IL-1 alpha), Is a Potential Fibrogenic Factor in Bronchiolitis Obliterans Syndrome (BOS)2011
Dr Elizabeth Moisey
Dr Lee Borthwick
Dr John Perry
Professor Anthony De Soyza
Professor Andrew Fisher
et al.
Cigarette smoke dysregulates pro-inflammatory cytokine release from airway epithelial cells and macrophages in response to haemophilus influenzae2010
Monika Suwara
Dr Lee Borthwick
Professor Jelena Mann
Professor Andrew Fisher
Professor Derek Mann
et al.
IL-1 IS A KEY EPITHELIAL ALARMIN WHICH PROMOTES FIBROBLAST ACTIVATION2010
Dr Lee Borthwick
Marta Gorowiec
Dr Malcolm Brodlie
Professor Christopher Ward
Dr James Lordan
et al.
Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair2010
Aaron Gardner
Dr Lee Borthwick
Professor Andrew Fisher
Lung epithelial wound healing in health and disease2010
Dr Laura Mackay
Dr Hannah Walden
Aaron Gardner
Dr Lee Borthwick
Professor Andrew Fisher
et al.
Microvascular endothelial cell apoptosis and dysregulation of vascular endothelial growth factor receptor 2 (VEGF-R2) in response to cigarette smoke. New insights into the pathogenesis of emphysema2010
Dr Lee Borthwick
Dr Malcolm Brodlie
Professor Christopher Ward
Dr John Perry
Emeritus Professor Nick Europe-Finner
et al.
The M1 macrophage phenotype accentuates TGF-beta 1 driven epithelial to mesenchymal transition (EMT) via the secretion of TNF alpha2010
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Professor Derek Mann
Dr Lee Borthwick
Professor Andrew Fisher
et al.
The role of transforming growth factor-beta activated kinase-1 (TAK-1) in the development of airway fibrosis2010
Dr Lee Borthwick
Dr Sean Parker
Kate Brougham
Marta Gorowiec
Professor Christopher Ward
et al.
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation2009
Dr Lee Borthwick
Clare Pate
Emeritus Professor Nick Europe-Finner
Dr Joaquim Majo
Professor Andrew Fisher
et al.
Morphometric comparison of airway remodelling in chronic obstructive pulmonary disease and obliterative bronchiolitis2009
Dr Lee Borthwick
Dr Malcolm Brodlie
Professor Christopher Ward
Dr James Lordan
Professor John Kirby
et al.
Pro-inflammatory Cytokines IL-1 beta and TNT alpha, but Not IL-8, Cause Aberrant Lung Epithelial Wound Repair Via TGF-beta 1 Driven Epithelial to Mesenchymal Transition (EMT)2009
Dr Lee Borthwick
Dr John Perry
Professor Andrew Fisher
Professor Anthony De Soyza
Proinflammatory potential of pseudomonas aeruginosa in macrophage models: Importance of clinical origin?2009
Dr Sean Parker
Dr Lee Borthwick
Professor Christopher Ward
Dr James Lordan
Emeritus Professor Nick Europe-Finner
et al.
Airway epithelial cell senescence in the lung allograft2008
Marta Gorowiec
Dr Lee Borthwick
Marcin Pekalski
Dr James Lordan
Emeritus Professor Nick Europe-Finner
et al.
Oxidative stress induces epithelial to mesenchymal transition in human lung epithelial cells through transforming groeth factor beta and integrin beta6-dependent mechanism2008
Dr Lee Borthwick
Kate Brougham
Professor Christopher Ward
Dr James Lordan
Professor John Kirby
et al.
Pro-inflammatory cytokines dysregulate lung epithelial wound repair via epithelial to mesenchymal transition2008
Dr Lee Borthwick
Sally Maloney
Dr Rachel Anderson
Professor Christopher Ward
Dr James Lordan
et al.
Transforming growth factor beta 1 suppresses secretory leucoprotease inhibitor release in response to infection in lung epithelial cells2008
Dr Lee Borthwick
Dr Sean Parker
Marta Gorowiec
Professor Christopher Ward
Dr James Lordan
et al.
Tumour necrosis factor-α accentuates transforming growth factor-β driven epithelial to mesenchymal transition (EMT) in airway epithelial cells from lung transplant recipients2008
Marta Gorowiec
Dr Sean Parker
Dr Lee Borthwick
Professor Christopher Ward
Dr James Lordan
et al.
Oxidative stress increases transforming growth factor-beta expression and drives epithelial to mesenchymal transition in human lung epithelial cells2007
Dr Rachel Anderson
Dr Lee Borthwick
Dr James Lordan
Emeritus Professor Nick Europe-Finner
Professor Andrew Fisher
et al.
The effect of calcineurin inhibitors (CNI) on the release of secretory leucoproteinase inhibitor (SLPI) by lung epithelial cells in the presence of transforming growth factor-beta (TGF-beta)2007
Dr Sean Parker
Marta Gorowiec
Dr Lee Borthwick
Dr James Lordan
Professor Christopher Ward
et al.
Transforming growth factor beta (TGF beta) induces cellular senescence in primary bronchial epithelial cells: A possible role in airway remodelling2007
Dr Lee Borthwick
Professor Christopher Ward
Dr James Lordan
Emeritus Professor Nick Europe-Finner
Professor Andrew Fisher
et al.
Epithelial mesencymal transition occurs in primary airway epithelial cells in response to transforming growth factor-beta and epidermal growth factor2006
Dr Lee Borthwick
Dr Sean Parker
Professor Christopher Ward
Emeritus Professor Nick Europe-Finner
Dr James Lordan
et al.
Oxidative stress induces epithelial to mesenchymal transition in bronchial epithelial cells: A possible role in airway remodelling2006
Dr Rachel Anderson
Dr Lee Borthwick
Emeritus Professor Nick Europe-Finner
Dr James Lordan
Professor Andrew Fisher
et al.
The effect of immunosuppressants on secretory leucoproteinase inhibitor production by lung epithelium in the presence of transforming growth factor-beta2006
Dr Lee Borthwick
Professor Christopher Ward
Dr James Lordan
Emeritus Professor Nick Europe-Finner
Professor Andrew Fisher
et al.
Tumour necrosis factor-alpha accentuates transforming growth factor-beta driven epithelial to mesenchymal transition in lung epithelial cells2006