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Three cases of the myelodysplastic syndrome with pericentric inversion of chromosome 16

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci

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Abstract

Inversion of chromosome 16, inv(16)(p13q22), is characteristic of acute myeloid leukaemia (AML) with eosinophilia and is rarely found in the myelodysplastic syndrome (MDS). We report three cases of MDS in which inv(16) was observed. They were classified to FAB subtypes RA, RARS and RAEBT; eosinophilia or abnormal eosinophils were not observed. The disease appeared to be stable in all three patients. MDS with inv(16) without eosinophilia may be a rare subgroup associated with a good prognosis.

Publication metadata

Author(s): Narayanan MN, Geary CG, Harrison CJ, Cinkotai KI, Lewis MJ

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 1993

Volume: 85

Issue: 1

Pages: 217-219

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2141.1993.tb08677.x

DOI: 10.1111/j.1365-2141.1993.tb08677.x

Notes: Case Reports

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