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Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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It has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.

Publication metadata

Author(s): Goyns MH, Hammond DW, Harrison CJ, Menasce LP, Ross FM, Hancock BW

Publication type: Article

Publication status: Published

Journal: Leukemia

Year: 1993

Volume: 7

Issue: 6

Pages: 848-52

Print publication date: 01/06/1993

ISSN (print): 0887-6924

ISSN (electronic): 1476-5551

Publisher: Nature Publishing Group