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Residual Ph- cells in chronic myeloid leukemia: detection and usefulness

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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Bone marrow cells from patients with chronic myeloid leukemia (CML) in in vitro long-term bone marrow culture (LTBMC) show an impaired survival of Philadelphia (Ph) positive cells and, in a proportion of patients, the emergence of Philadelphia negative hemopoiesis. The standard conditions of in vitro cultures provide optimal purging effect. Selected patients can now have autologous bone marrow transplants (ABMT) with in vitro purged cells.

Publication metadata

Author(s): Chang J, Coutinho LH, Santos AMW, Brereton M, Harrison CJ, Testa NG

Publication type: Article

Publication status: Published

Journal: Stem Cells

Year: 1993

Volume: 11

Issue: Suppl 1

Pages: 59-61

Print publication date: 01/05/1993

ISSN (print): 1066-5099

ISSN (electronic): 1549-4918

Publisher: AlphaMed Press, Inc.


DOI: 10.1002/stem.5530110612

Notes: Journal Article Research Support, Non-U.S. Gov't United states Supplementary Issue: Proceedings of the Conference Celebrating the 40th Anniversary of the Institute of Hematology and Blood Transfusion


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