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Lookup NU author(s): Emeritus Professor Jan Scott
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Early onset of heroin use is a severity marker of heroin use disorder. We studied the interaction between early onset and rapid transition to heroin dependence recorded with retrospective interviews in 213 patients with severe heroin dependence and history of methadone maintenance treatment. General linear models were used to identify independent factors associated with early onset, factors associated with rapid transition to dependence, and a multivariate model was used to study the interaction of those two dimensions. Lifetime history of anxiety disorders and age at onset of cannabis use are shared common risk factors and are associated with the interaction.
Author(s): Karsinti E, Fortias M, Dupuy G, Ksouda K, Laqueille X, Simonpoli AM, Touzeau D, Avril E, Orizet C, Belforte B, Coeuru P, Polomeni P, Icick R, Jarroir M, Bloch V, Scott J, Lepine JP, Bellivier F, Vorspan F
Publication type: Article
Publication status: Published
Journal: Psychiatry Research
Print publication date: 30/11/2016
Online publication date: 19/07/2016
Acceptance date: 20/04/2016
ISSN (print): 0165-1781
ISSN (electronic): 1872-7123
Publisher: Elsevier Ireland Ltd
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