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Anxiety disorders are associated with early onset of heroin use and rapid transition to dependence in methadone maintained patients

Lookup NU author(s): Emeritus Professor Jan Scott


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Early onset of heroin use is a severity marker of heroin use disorder. We studied the interaction between early onset and rapid transition to heroin dependence recorded with retrospective interviews in 213 patients with severe heroin dependence and history of methadone maintenance treatment. General linear models were used to identify independent factors associated with early onset, factors associated with rapid transition to dependence, and a multivariate model was used to study the interaction of those two dimensions. Lifetime history of anxiety disorders and age at onset of cannabis use are shared common risk factors and are associated with the interaction.

Publication metadata

Author(s): Karsinti E, Fortias M, Dupuy G, Ksouda K, Laqueille X, Simonpoli AM, Touzeau D, Avril E, Orizet C, Belforte B, Coeuru P, Polomeni P, Icick R, Jarroir M, Bloch V, Scott J, Lepine JP, Bellivier F, Vorspan F

Publication type: Article

Publication status: Published

Journal: Psychiatry Research

Year: 2016

Volume: 245

Pages: 423-426

Print publication date: 30/11/2016

Online publication date: 19/07/2016

Acceptance date: 20/04/2016

ISSN (print): 0165-1781

ISSN (electronic): 1872-7123

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.psychres.2016.04.064


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Funder referenceFunder name
OST07013DRCD (Direction de la Recherche Clinique et du Developpement) of the Assistance Publique - Hopitaux de Paris (Optimisation des Strategies Therapeutiques)
ASE07082KSAMILDT (Mission Inter-Ministerielle de Lutte Contre la Drogue et la Toxicomanie)