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Dendritic cell analysis in primary immunodeficiency

Lookup NU author(s): Dr Venetia Bigley, Professor Matthew Collin

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Purpose of reviewDendritic cells are specialized antigen-presenting cells which link innate and adaptive immunity, through recognition and presentation of antigen to T cells. Although the importance of dendritic cells has been demonstrated in many animal models, their contribution to human immunity remains relatively unexplored in vivo.Given their central role in infection, autoimmunity, and malignancy, dendritic cell deficiency or dysfunction would be expected to have clinical consequences.Recent findingsHuman dendritic cell deficiency disorders, related to GATA binding protein 2 (GATA2) and interferon regulatory factor 8 (IRF8) mutations, have highlighted the importance of dendritic cells and monocytes in primary immunodeficiency diseases and begun to shed light on their nonredundant roles in host defense and immune regulation in vivo. The contribution of dendritic cell and monocyte dysfunction to the pathogenesis of primary immunodeficiency disease phenotypes is becoming increasingly apparent. However, dendritic cell analysis is not yet a routine part of primary immunodeficiency disease workup.SummaryWidespread uptake of dendritic cell/monocyte screening in clinical practice will facilitate the discovery of novel dendritic cell and monocyte disorders as well as advancing our understanding of human dendritic cell biology in health and disease.


Publication metadata

Author(s): Bigley V, Barge D, Collin M

Publication type: Review

Publication status: Published

Journal: Current Opinion in Allergy & Clinical Immunology

Year: 2016

Volume: 16

Issue: 6

Pages: 530-540

Print publication date: 01/12/2016

Acceptance date: 01/01/1900

ISSN (print): 1528-4050

ISSN (electronic): 1473-6322

Publisher: LIPPINCOTT WILLIAMS & WILKINS

URL: http://dx.doi.org/10.1097/ACI.0000000000000322

DOI: 10.1097/ACI.0000000000000322


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