Toggle Main Menu Toggle Search

Open Access padlockePrints

Insights from echocardiography, magnetic resonance imaging, and microcomputed tomography relative to the mid-myocardial left ventricular echogenic zone

Lookup NU author(s): Professor Bob Anderson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


BackgroundThe anatomical substrate for the mid-mural ventricular hyperechogenic zone remains uncertain, but it may represent no more than ultrasound reflected from cardiomyocytes orientated orthogonally to the ultrasonic beam. We sought to ascertain the relationship between the echogenic zone and the orientation of the cardiomyocytes.MethodsWe used 3D echocardiography, diffusion tensor imaging, and microcomputed tomography to analyze the location and orientation of cardiomyocytes within the echogenic zone.ResultsWe demonstrated that visualization of the echogenic zone is dependent on the position of the transducer and is most clearly seen from the apical window. Diffusion tensor imaging and microcomputed tomography show that the echogenic zone seen from the apical window corresponds to the position of the circumferentially orientated cardiomyocytes. An oblique band seen in the parasternal view relates to cardiomyocytes orientated orthogonally to the ultrasonic beam.ConclusionsThe mid-mural ventricular hyperechogenic zone represents reflected ultrasound from cardiomyocytes aligned orthogonal to the ultrasonic beam. The echogenic zone does not represent a space, a connective tissue sheet, a boundary between ascending and descending limbs of a hypothetical helical ventricular myocardial band, nor an abrupt change in cardiomyocyte orientation.

Publication metadata

Author(s): Agger P, Stephenson RS, Dobrzynski H, Atkinson A, Iaizzo PA, Anderson RH, Jarvis JC, Allan SL, Partridge JB, Zhao JC, Zhang HG, MacIver DH

Publication type: Article

Publication status: Published

Journal: Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques

Year: 2016

Volume: 33

Issue: 10

Pages: 1546-1556

Online publication date: 26/10/2016

Acceptance date: 01/01/1900

ISSN (print): 0742-2822

ISSN (electronic): 1540-8175

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/echo.13324


Altmetrics provided by Altmetric