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Lookup NU author(s): Harbaljit Sohal, Dr Gavin ClowryORCiD, Professor Andrew Jackson, Professor Anthony O'Neill, Professor Stuart BakerORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Micromotion between the brain and implanted electrodes is a major contributor to the failure of invasive microelectrodes. Movements of the electrode tip cause recording instabilities while spike amplitudes decline over the weeks/months post-implantation due to glial cell activation caused by sustained mechanical trauma. We compared the glial response over a 26-96 week period following implantation in the rabbit cortex of microwires and a novel flexible electrode. Horizontal sections were used to obtain a depth profile of the radial distribution of microglia, astrocytes and neurofilament. We found that the flexible electrode was associated with decreased gliosis compared to the microwires over these long indwelling periods. This was in part due to a decrease in overall microgliosis and enhanced neuronal density around the flexible probe, especially at longer periods of implantation.
Author(s): Sohal HS, Clowry GJ, Jackson A, O'Neill A, Baker SN
Publication type: Article
Publication status: Published
Journal: PLoS One
Year: 2016
Volume: 11
Issue: 10
Online publication date: 27/10/2016
Acceptance date: 15/10/2016
Date deposited: 17/01/2017
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
URL: http://dx.doi.org/10.1371/journal.pone.0165606
DOI: 10.1371/journal.pone.0165606
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