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Physical and mental health burden in cases of bipolar disorder classified as current, former, or non-tobacco smokers

Lookup NU author(s): Emeritus Professor Jan Scott


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Background: Tobacco smoking increases the global burden of bipolar disorder (BD). We examined markers of physical and mental health that are associated with tobacco smoking, controlling for confounders that have not always been considered in previous studies of BD.Methods: Over 600 individuals with BD I or II referred to the French Network for bipolar disorder (FACE-BD) who completed standardized assessments, and could be reliably classified as current (CS) or former smokers (FS), were compared with those who were never smokers (NS) on: BD symptom load and psychiatric comorbidities; prevalence of alcohol and substance use disorders (ASUD); medication usage; functioning and physical health parameters. The bivariate and multivariate analyses took into account age and gender.Results: 300 cases (49%) were CS, 78 (13%) FS and 238 (39%) had never smoked. Rates were similar across genders regardless of BD subtype. Compared with NS, CS were more likely to have an ASUD (Odds Ratio (OR) 5.18), BD I (OR 2.09), and lower abdominal obesity (OR 0.97), and FS were more likely to have an ASUD (OR 6.32) and higher abdominal obesity (OR 1.03).Limitations: The sample comprised of white Europeans; the FS subgroup was relatively small and we did not apply any statistical correction for the bivariate analyses.Conclusions: The increased risk of physical and mental health burden in CS and FS compared to NS represents avoidable morbidity in BD. This study offers support to the argument that individuals with BD should be routinely offered support to prevent or stop tobacco smoking.

Publication metadata

Author(s): Icick R, Gard S, Barde M, Carminati M, Desage A, Guillaume S, Scott J, Bellivier F, FondaMental Adv Ctr Expertise Bipo

Publication type: Article

Publication status: Published

Journal: Journal of Affective Disorders

Year: 2017

Volume: 208

Pages: 406-413

Print publication date: 15/01/2017

Online publication date: 23/09/2016

Acceptance date: 22/09/2016

ISSN (print): 0165-0327

ISSN (electronic): 1573-2517

Publisher: Elsevier Science BV.


DOI: 10.1016/j.jad.2016.09.022


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Funder referenceFunder name
FondaMental Foundation, Creteil, France
ANR-10-COHO-10-01Investissements d'Avenir Programs
ANR-11-IDEX-0004-02Investissements d'Avenir Programs