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Blood Spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukemia. Breakage-fusion-bridge cycles followed by chromothripsis and other complex structural rearrangements of chromosome 21 underlie the mechanism giving rise to iAMP21. Patients with iAMP21 are older (median age 9 years), with a low white cell count. They have a high relapse rate when treated as standard risk. Recent studies have shown improved outcome on intensive therapy. Molecular targets for therapy are being sought.

Publication metadata

Author(s): Harrison CJ

Publication type: Article

Publication status: Published

Journal: Blood

Year: 2015

Volume: 125

Issue: 9

Pages: 1383-1386

Print publication date: 26/02/2015

Online publication date: 21/01/2015

Acceptance date: 01/01/1900

ISSN (print): 0006-4971

ISSN (electronic): 1528-0020

Publisher: American Society of Hematology


DOI: 10.1182/blood-2014-08-569228


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