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The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Function: The EGIR-RISC Study

Lookup NU author(s): Professor Mark Walker


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Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing.Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and beta-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort.Design, Setting, Participants, and Measures: We used data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and beta-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and beta-cell function were analyzed by multiple linear regression, stratified by sex.Results: In our current analysis, we included 788 participants (57% women, age 44 +/- 8 y), who had an average sleep duration of 7.3 +/- 1.5 hours. In men, weobserved an inverted U-shaped association between sleep duration categorized per hour and M/I (in mu mol/min per kg(FFM)/nM per hour) (beta-estimate [95% confidence intervals] 41 [2, 80]; P = .04 and beta(2)-estimate - 3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kg(FFM)) (beta-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and beta-cell function (in pmol/min per m(2)/mM per hour) (beta-estimate -45 [-86, -3]; P = .04 and beta(2)-estimate 3 [0.2, 6]; P = .04).Conclusions: Sleep duration is associated with insulin sensitivity and beta-cell function in a sex-specific manner in clinically healthy people.

Publication metadata

Author(s): Rutters F, Besson H, Walker M, Mari A, Konrad T, Nilsson PM, Balkau B, Dekker JM

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Endocrinology & Metabolism

Year: 2016

Volume: 101

Issue: 9

Pages: 3272-3280

Print publication date: 01/09/2016

Online publication date: 29/06/2016

Acceptance date: 12/05/2016

ISSN (print): 0021-972X

ISSN (electronic): 1945-7197

Publisher: Endocrine Society


DOI: 10.1210/jc.2016-1045


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Funder referenceFunder name
AstraZeneca, Sweden
Merck, France
QLG1-CT-2001-01252European Union