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Cortical network oscillations in Alzheimer's disease: insights from rodent models

Lookup NU author(s): Dr Fiona LeBeau


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Transgenic mouse models of Alzheimer's disease (AD) have been used extensively for several years to study the consequences of AD pathology on cortical circuits. Numerous studies have focused on changes in hippocampal function, in particular, memory, synaptic transmission and synaptic plasticity. This review focuses on changes in network activity in mouse models of AD, particularly low gamma (30-80 Hz) frequency oscillations as this rhythm is thought to underlie some of the cognitive functions that are impaired in AD. © 2014 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): LeBeau FEN

Publication type: Article

Publication status: Published

Journal: Drug Discovery Today: Therapeutic Strategies

Year: 2013

Volume: 10

Issue: 2

Pages: e79-e83

Print publication date: 01/06/2013

Online publication date: 23/06/2014

Acceptance date: 01/01/1900

ISSN (print): 1740-6773

ISSN (electronic): 1740-6773

Publisher: Elsevier


DOI: 10.1016/j.ddstr.2014.05.001


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