Mesenchymal Stem Cells for Diabetes and Related Complications

Volarevic, V; Lako, M; Stojkovic, M

doi:10.1007/978-94-007-6716-4_14

Mesenchymal Stem Cells for Diabetes and Related Complications

Lookup NU author(s): Professor Majlinda Lako ORCiD, Professor Miodrag Stojkovic

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© Springer Science+Business Media Dordrecht 2013.Mesenchymal stem cells (MSCs) are self-renewing cells with multipotent differentiation characteristics and capability for the regulation of immune response. Accordingly, in the context of diabetes research, the ability of MSC to generate insulin-producing cells and to enhance islet engraftment and survival makes them attractive as new therapeutic agents for treatment of diabetes and related complications. In this chapter we emphasized the role of MSCs in the repair of cell mass and function and we described the capacity of MSCs to modulate the autoimmune response during the pathogenesis of diabetes mellitus. In addition, we also presented here the mechanisms, promises and potential obstacles for MSC therapy of diabetic complications: cardiomyopathy, critical limb ischemia, nephropathy, polyneuropathy, retinopathy and diabetic wounds.