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Mesenchymal Stem Cells for Diabetes and Related Complications

Lookup NU author(s): Professor Majlinda LakoORCiD, Professor Miodrag Stojkovic


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© Springer Science+Business Media Dordrecht 2013.Mesenchymal stem cells (MSCs) are self-renewing cells with multipotent differentiation characteristics and capability for the regulation of immune response. Accordingly, in the context of diabetes research, the ability of MSC to generate insulin-producing cells and to enhance islet engraftment and survival makes them attractive as new therapeutic agents for treatment of diabetes and related complications. In this chapter we emphasized the role of MSCs in the repair of cell mass and function and we described the capacity of MSCs to modulate the autoimmune response during the pathogenesis of diabetes mellitus. In addition, we also presented here the mechanisms, promises and potential obstacles for MSC therapy of diabetic complications: cardiomyopathy, critical limb ischemia, nephropathy, polyneuropathy, retinopathy and diabetic wounds.

Publication metadata

Author(s): Volarevic V, Lako M, Stojkovic M

Editor(s): Robert Chunhua Zhao

Publication type: Book Chapter

Publication status: Published

Book Title: Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation

Year: 2013

Pages: 207-227

Online publication date: 29/04/2013

Publisher: Springer

Place Published: Dordrecht


DOI: 10.1007/978-94-007-6716-4_14

Library holdings: Search Newcastle University Library for this item

ISBN: 9789400767157