Browse by author
Lookup NU author(s): Professor Mark Walker
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2014 Elsevier Ireland Ltd.The incidence of type 2 diabetes (T2D) is rapidly increasing worldwide and T2D is likely to affect 592 million people in 2035 if the current rate of progression is continued. Today, patients are diagnosed with T2D based on elevated blood glucose, either directly or indirectly (HbA1c). However, the information on disease progression is limited.Therefore, there is a need to identify novel early markers of glucose intolerance that reflect the underlying biology and the overall physiological, metabolic and clinical characteristics of progression towards diabetes.In the DEXLIFE study, several clinical cohorts provide the basis for a series of clinical, physiological and mechanistic investigations in combination with a range of - omic technologies to construct a detailed metabolic profile of high-risk individuals across multiple cohorts.In addition, an exercise and dietary intervention study is conducted, that will assess the impact on both plasma biomarkers and specific functional tissue-based markers.The DEXLIFE study will provide novel diagnostic and predictive biomarkers which may not only effectively detect the progression towards diabetes in high risk individuals but also predict responsiveness to lifestyle interventions known to be effective in the prevention of diabetes.
Author(s): Andersen GS, Thybo T, Cederberg H, Oresic M, Esteller M, Zorzano A, Carr B, Walker M, Cobb J, Clissmann C, O'Gorman DJ, Nolan JJ, on behalf of the DEXLIFE Consortium
Publication type: Article
Publication status: Published
Journal: Diabetes Research and Clinical Practice
Year: 2014
Volume: 106
Issue: 2
Pages: 383-389
Print publication date: 01/11/2014
Online publication date: 27/07/2014
Acceptance date: 20/07/2014
ISSN (print): 0168-8227
ISSN (electronic): 1872-8227
Publisher: Elsevier Ireland Ltd
URL: https://doi.org/10.1016/j.diabres.2014.07.025
DOI: 10.1016/j.diabres.2014.07.025
PubMed id: 25125339
Altmetrics provided by Altmetric
