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Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia

Lookup NU author(s): Mary Johnson, Professor Johannes Attems, Dr Clive Ballard, Professor Alan ThomasORCiD, Professor John O'Brien, Dr Dag Aarsland



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2014 Vallortigara J et al.Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD) together, represent the second most common cause of dementia, after Alzheimer's disease (AD). The synaptic dysfunctions underlying the cognitive decline and psychiatric symptoms observed throughout the development of PDD and DLB are still under investigation. In this study we examined the expression level of Dynamin1 and phospho-CaMKII, key proteins of endocytosis and synaptic plasticity respectively, as potential markers of molecular processes specifically deregulated with DLB and/or PDD. In order to measure the levels of these proteins, we isolated grey matter from post-mortem prefrontal cortex area (BA9), anterior cingulated gyrus (BA24) and parietal cortex (BA40) from DLB and PDD patients in comparison to age-matched controls and a group of AD cases. Clinical and pathological data available included the MMSE score, neuropsychiatric history, and semi-quantitative scores for AD pathology (plaques - tangles) and for α-synuclein (Lewy bodies). Changes in the expression of the synaptic markers, and correlates with neuropathological features and cognitive decline were predominantly found in the prefrontal cortex. On one hand, levels of Dynamin1 were significantly reduced, and correlated with a higher rate of cognitive decline observed in cases from three dementia groups. On the other hand, the fraction of phospho-CaMKII was decreased, and correlated with a high score of plaques and tangles in BA9. Interestingly, the correlation between the rate of cognitive decline and the level of Dynamin1 remained when the analysis was restricted to the PDD and DLB cases, highlighting an association of Dynamin1 with cognitive decline in people with Lewy Body dementia.

Publication metadata

Author(s): Vallortigara J, Rangarajan S, Whitfield D, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, Attems J, Ballard C, Thomas A, O'Brien J, Aarsland D, Francis P

Publication type: Article

Publication status: Published

Journal: F1000Research

Year: 2014

Volume: 3

Online publication date: 13/05/2014

Acceptance date: 01/01/1900

Date deposited: 29/01/2018

ISSN (electronic): 2046-1402

Publisher: Faculty of 1000 Ltd


DOI: 10.12688/f1000research.3786.1


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Funder referenceFunder name
R173/1110Dunhill Medical Trust