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Epigenetic regulation of hepatic stellate cells and liver fibrosis

Lookup NU author(s): Professor Jelena Mann, Professor Derek Mann


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© 2015 by John Wiley & Sons, Ltd. All rights reserved. Epigenetics is a field of biology that is generating considerable excitement in modern medicine, principally because it can explain how the interactions of our genetic background with the environment and our age-acquired experiences influence vitality and health as we progress through middle to old age. Importantly, epigenetic processes are highly dynamic and can be modified by environmental factors and drugs, which raises the real possibility of epigenetic therapies. Furthermore, there is growing interest in the concept that there may be dynamic epigenetic mechanisms that impact on the germline such that phenotypes acquired in the adult may be transmitted independently of DNA sequence to children and grandchildren, potentially influencing life choices (e.g. diet, alcohol, even exercise) and disease susceptibility.

Publication metadata

Author(s): Mann J, Mann DA

Publication type: Book Chapter

Publication status: Published

Book Title: Signaling Pathways in Liver Diseases

Year: 2015

Pages: 421-434

Online publication date: 28/08/2015

Acceptance date: 01/01/1900

Edition: 3

Publisher: Wiley Blackwell

DOI: 10.1002/9781118663387.ch31

Library holdings: Search Newcastle University Library for this item

ISBN: 9781118663387