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Decreasing prevalence in cerebral palsy: A multi-site European population-based study, 1980 to 2003

Lookup NU author(s): Emeritus Professor Allan ColverORCiD, Professor Lindsay Pennington


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© 2016 Mac Keith Press. Aim: To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003. Method: Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]). Results: The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births. Interpretation: The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.

Publication metadata

Author(s): Sellier E, Platt MJ, Andersen GL, Krageloh-Mann I, De La Cruz J, Cans C, Cans C, Van Bakel M, Arnaud C, Delobel M, Chalmers J, McManus V, Lyons A, Parkes J, Dolk H, Himmelmann K, Pahlman M, Dowding V, Colver A, Pennington L, Horridge K, Kurinczuk J, Surman G, Platt MJ, Udall P, Rackauskaite G, Torrioli MG, Marcelli M, Andersen G, Julsen Hollung S, Bottos M, Gaffney G, De la Cruz J, Pallas C, Neubauer D, Jekovec-Vrhovsek M, Virella D, Andrada M, Greitane A, Hollody K, Sigurdardottir S, Einarsson I, Honold M, Rostasy K, Mejaski-Bosnjak V

Publication type: Article

Publication status: Published

Journal: Developmental Medicine and Child Neurology

Year: 2016

Volume: 58

Issue: 1

Pages: 85-92

Print publication date: 01/01/2016

Online publication date: 28/08/2015

Acceptance date: 30/06/2015

ISSN (print): 0012-1622

ISSN (electronic): 1469-8749

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/dmcn.12865

PubMed id: 26330098


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