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Protecting the kidney from complement: atypical haemolytic uraemic syndrome

Lookup NU author(s): Dr Vicky Brocklebank, Professor David KavanaghORCiD


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© 2014 Royal College of Physicians. Atypical haemolytic uraemic syndrome is a thrombotic microangiopathy with a predominant renal phenotype. Research developments in the last 15 years have led to the elucidation of the role of complement over activation in the pathogenesis of the disease. This was to lead to the successful introduction of targeted pharmacological therapy, in the form of the complement inhibitor, eculizumab.

Publication metadata

Author(s): Brocklebank V, Kavanagh D

Publication type: Review

Publication status: Published

Journal: Clinical Medicine

Year: 2014

Volume: 14

Issue: suppl. 6

Pages: s89-s94

Print publication date: 01/12/2014

Acceptance date: 01/01/1900

ISSN (print): 1473-4893


DOI: 10.7861/clinmedicine.14-6-s89

PubMed id: 25468928