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Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?

Lookup NU author(s): Dr Louise Reynard

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Abstract

© 2016 The Author Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is complex and highly heritable, with genetic variation estimated to contribute to 50% of OA occurrence. Epigenetic alterations, including DNA methylation changes, have also been implicated in OA pathophysiology. This review examines what genetic and DNA methylation studies have taught us about the genes and pathways involved in OA pathology. The influence of DNA methylation on the molecular mechanisms underlying OA genetic risk and the consequence of this interaction on disease susceptibility and penetrance are also discussed.

Publication metadata

Author(s): Reynard LN

Publication type: Review

Publication status: Published

Journal: Seminars in Cell and Developmental Biology

Year: 2017

Volume: 62

Pages: 57-66

Print publication date: 01/02/2017

Online publication date: 26/04/2016

Acceptance date: 25/04/2016

ISSN (print): 1084-9521

ISSN (electronic): 1096-3634

Publisher: Academic Press

URL: https://doi.org/10.1016/j.semcdb.2016.04.017

DOI: 10.1016/j.semcdb.2016.04.017

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