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Molecular Pathways and Animal Models of Atrial Septal Defect

Lookup NU author(s): Professor Bob Anderson


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© Springer-Verlag Wien 2016. The seeming simplicity of the clinical presentation and management of an atrial septal defect belies the complexity of the developmental pathogenesis. Here, we describe the anatomic development of the atrial septum and the venous return to the atrial chambers. Recent experimental results suggest where genetic mutations could disrupt developmental steps to cause a defect within the oval fossa, the so-called secundum defect or other interatrial communication, such as the sinus venosus defect.

Publication metadata

Author(s): Jay PY, Degenhardt KR, Anderson RH

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways

Year: 2015

Pages: 291-300

Print publication date: 18/12/2015

Acceptance date: 01/01/1900

Publisher: Springer-Verlag Wien


DOI: 10.1007/978-3-7091-1883-2_21

Library holdings: Search Newcastle University Library for this item

ISBN: 9783709118832