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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Lookup NU author(s): Professor Tim Goodship


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© 2016 International Society of Nephrology In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.

Publication metadata

Author(s): Goodship THJ, Cook HT, Fakhouri F, Fervenza FC, Fremeaux-Bacchi V, Kavanagh D, Nester CM, Noris M, Pickering MC, Rodriguez de Cordoba S, Roumenina LT, Sethi S, Smith RJH, Alpers CE, Appel GB, Ardissino G, Ariceta G, Arici M, Bagga A, Bajema IM, Blasco M, Burke L, Cairns TD, Carratala M, D'Agati VD, Daha MR, De Vriese AS, Dragon-Durey M-A, Fogo AB, Galbusera M, Gale DP, Haller H, Johnson S, Jozsi M, Karpman D, Lanning L, Le Quintrec M, Licht C, Loirat C, Monfort F, Morgan BP, Noel L-H, O'Shaughnessy MM, Rabant M, Rondeau E, Ruggenenti P, Sheerin NS, Smith J, Spoleti F, Thurman JM, van de Kar NCAJ, Vivarelli M, Zipfel PF

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Kidney International

Year of Conference: 2017

Pages: 539-551

Publisher: Elsevier B.V.

DOI: 10.1016/j.kint.2016.10.005