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Lookup NU author(s): Dr Jodie Birch,
Dr Joao Passos
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 WILEY Periodicals, Inc. Anti-senescence therapies, such as drugs that specifically kill senescent cells, to stave off ageing are currently under investigation. While these interventions show promise, their potential pitfalls are discussed herein. We have shown that the mitochondria are essential for development of senescence and many of the associated phenotypes, including the often detrimental senescence-associated secretory phenotype (SASP). Here, we disentangle many ways in which the mitochondria may influence senescence and development of the SASP and focus on possible pathways that could be exploited for future generation of anti-senescence therapies with a clear aim; to specifically eliminate the problematic features of senescent cells, while maintaining their beneficial characteristics.
Author(s): Birch J, Passos JF
Publication type: Article
Publication status: Published
Print publication date: 01/05/2017
Online publication date: 20/02/2017
Acceptance date: 02/04/2016
Date deposited: 16/05/2017
ISSN (print): 0265-9247
ISSN (electronic): 1521-1878
Publisher: John Wiley and Sons Inc.
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