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Apical Sodium-Dependent Transporter Inhibitors in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Lookup NU author(s): Dr Vinod Hegade, Professor David Jones

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Abstract

© 2017 S. Karger AG, Basel. Bile acids (BAs) have gained mainstream attention since the discovery of their key role as signalling molecules in health and disease. The apical sodium-dependent transporter (ASBT) protein located in the terminal ileum plays an important physiological role in the enterohepatic circulation of BAs and therefore essential for the BA homeostasis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), the 2 most common cholestatic liver diseases are characterised by altered BA flow and BA composition, which contribute to disease progression and symptom (pruritus) development. Therefore, changing the circulating BA pool in patients with PBC and PSC may have therapeutic implications. To this end, pharmacological inhibition of ASBT is fast emerging as an interesting target. In this review, we discuss the recent evidence for potential therapeutic use of ASBT inhibitors to treat PBC and PSC patients.

Publication metadata

Author(s): Hegade VS, Jones DEJ, Hirschfield GM

Publication type: Article

Publication status: Published

Journal: Digestive Diseases

Year: 2017

Volume: 35

Issue: 3

Pages: 267-274

Print publication date: 01/03/2017

Online publication date: 01/03/2017

Acceptance date: 02/04/2016

ISSN (print): 0257-2753

ISSN (electronic): 1421-9875

Publisher: S. Karger AG

URL: https://doi.org/10.1159/000450988

DOI: 10.1159/000450988

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