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Acute myeloid leukemia

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci

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Abstract

© 2015 John Wiley & Sons, Ltd. Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender, geographic/ethnic origin, and constitutional genetics. This chapter summarizes the cytogenetic, molecular genetic and clinical features of AML-associated numerical and structural abnormalities. It explains the characteristic karyotypic patterns in AML. Complex Karyotypic (CK), monosomal Karyotype (MK), normal Karyotype (NK) are the chromosomal abnormalities reported in AML.


Publication metadata

Author(s): Johansson B, Harrison CJ

Publication type: Book Chapter

Publication status: Published

Book Title: Cancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells, Fourth Edition

Year: 2015

Pages: 62-125

Print publication date: 26/06/2015

Online publication date: 03/09/2015

Acceptance date: 01/01/1900

Edition: 4

Publisher: Wiley Blackwell

URL: http://doi.org/10.1002/9781118795569.ch6

DOI: 10.1002/9781118795569.ch6

Library holdings: Search Newcastle University Library for this item

ISBN: 9781118795569


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